Ground-glass opacity heralding invasive lung adenocarcinoma with prodromal dermatomyositis: a case report.
| Autor: | Beel AJ; Stanford University School of Medicine, Stanford, USA., Demos DS; Division of Thoracic Surgery, Stanford University School of Medicine, Falk Building, 300 Pasteur Drive, Stanford, 94305, USA., Chung A; Division of Oncology, Stanford University School of Medicine / Stanford Cancer Institute, Stanford, USA., Liao C; Division of Hospital Medicine, Stanford University School of Medicine, Stanford, USA., Lui NS; Division of Thoracic Surgery, Stanford University School of Medicine, Falk Building, 300 Pasteur Drive, Stanford, 94305, USA. natalielui@stanford.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of cardiothoracic surgery [J Cardiothorac Surg] 2018 Feb 07; Vol. 13 (1), pp. 20. Date of Electronic Publication: 2018 Feb 07. |
| DOI: | 10.1186/s13019-018-0705-x |
| Abstrakt: | Background: Dermatomyositis, an inflammatory myopathy with cutaneous involvement, is associated with malignancy and often manifests paraneoplastically. While co-occurrence with small cell carcinoma is well attested, primary lung adenocarcinoma, which may present as focal ground-glass opacification on computed tomography of the thorax, is less frequently coincident. Case Presentation: We report the case of a 72-year-old female patient with dermatomyositis - treated with a combination of prednisone, methotrexate, and intravenous immunoglobulin - and an indolent, subsolid, non-hypermetabolic pulmonary lesion, which was determined to be invasive primary lung adenocarcinoma. Supporting a paraneoplastic basis, immunosuppressive therapy was discontinued following tumor excision without relapse of signs or symptoms of dermatomyositis. Conclusions: While dermatomyositis prodromal to lung adenocarcinoma is not without precedent, association with an indolent, subsolid lesion has, to the best of our knowledge, not been reported. The case described herein illustrates the importance of maintaining a high index of suspicion for malignancy in the setting of dermatomyositis. |
| Databáze: | MEDLINE |
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