Flow velocity maps measured by nuclear magnetic resonance in medical intravenous catheter needleless connectors.

Autor: Nybo E; Department of Chemical and Biological Engineering, Montana State University, Bozeman, MT, USA., Maneval JE; Department of Chemical Engineering, Bucknell University, Lewisburg, PA, USA., Codd SL; Department of Mechanical and Industrial Engineering, Montana State University, Bozeman, MT, USA., Ryder MA; Ryder Science, Inc., Brentwood, TN, USA., James GA; Center for Biofilm Engineering, Montana State University, Bozeman, MT, USA., Woodbury J; ICU Medical, Inc., San Clemente, CA, USA., Seymour JD; Department of Chemical and Biological Engineering, Montana State University, Bozeman, MT, USA; Center for Biofilm Engineering, Montana State University, Bozeman, MT, USA. Electronic address: jseymour@montana.edu.
Jazyk: angličtina
Zdroj: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2018 Apr 15; Vol. 152, pp. 1-11. Date of Electronic Publication: 2018 Feb 03.
DOI: 10.1016/j.jpba.2018.01.037
Abstrakt: This work explains the motivation, advantages, and novel approach of using velocity magnetic resonance imaging (MRI) for studying the hydrodynamics in a complicated structural biomedical device such as an intravenous catheter needleless connector (NC). MRI was applied as a non-invasive and non-destructive technique to evaluate the fluid dynamics associated with various internal designs of the NC. Spatial velocity maps of fluid flow at specific locations within these medical devices were acquired. Dynamic MRI is demonstrated as an effective method to quantify flow patterns and fluid dynamic dependence on structural features of NCs. These spatial velocity maps could be used as a basis for groundtruthing computational fluid dynamics (CFD) methods that could impact the design of NCs.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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