An aptamer-Fe 3+ modified nanoparticle for lactate oxidation and tumor photodynamic therapy.

Autor: Yang H; School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, 212013, PR China., Lu WL; School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, 212013, PR China., Huang T; School of Pharmacy, Jiangsu University, Zhenjiang, 212013, PR China., Chen QY; School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, 212013, PR China. Electronic address: chenqy@ujs.edu.cn., Gao J; School of Pharmacy, Jiangsu University, Zhenjiang, 212013, PR China., Zhao Y; Beijing National Laboratory for Molecular Science, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, PR China.
Jazyk: angličtina
Zdroj: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2018 Apr 01; Vol. 164, pp. 192-200. Date of Electronic Publication: 2018 Feb 03.
DOI: 10.1016/j.colsurfb.2018.01.045
Abstrakt: To develop a cancer targeting lactate attenuator in vivo for cancer phototherapy and inhibition of HIF-1, we report an aptamer modified photo-responsive nanoparticle (labeled as Mn-D@BPFe-A) for lactate oxidation and cancer phototherapy. Mn-D@BPFe-A was constructed by the assembly of functional complex with BSA, followed by surface metal coordination and the recognition of Fe 3+ with GAG containing sequence. Upon irradiation, Mn-D@BPFe-A NPs can oxidize water with the generation of OH, which convert lactate into pyruvate both in vitro and in vivo. Obviously, the Mn-D@BPFe-A exhibits a significant tumor ablation owing to the light driven oxidation of lactic acid and dysfunction of mitochondria. Importantly, it can decrease both the level of lactate in cancer tissues and the expression of HIF-1α and Glut-1 in HepG-2 cells. These results demonstrated that oxidation of lactate with dysfunction of mitochondria by nucleic acid-Fe 3+ modified nanoparticle is an effective strategy for the development of non-oxygen dependent photodynamic effect agents.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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