Interactions Between Bisphenol A Exposure and GSTP1 Polymorphisms in Childhood Asthma.

Autor:	Lin TJ; Department of Neurosurgery, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Sports Science, College of Exercise and Health Sciences, National Taiwan Sport University, Taoyuan City, Taiwan.; Graduate Institute of Injury Prevention and Control, Taipei Medical University, Taipei, Taiwan., Karmaus WJJ; Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA., Chen ML; Institute of Environmental and Occupational Health Sciences, National Yang Ming University, Taipei, Taiwan., Hsu JC; Department of Internal Medicine, Taipei Hospital, Ministry of Health and Welfare, Taipei, Taiwan., Wang IJ; Department of Pediatrics, Taipei Hospital, Ministry of Health and Welfare, Taipei, Taiwan.; School of Medicine, National Yang Ming University, Taipei, Taiwan.; College of Public Health, China Medical University, Taichung, Taiwan. wij636@gmail.com.
Jazyk:	angličtina
Zdroj:	Allergy, asthma & immunology research [Allergy Asthma Immunol Res] 2018 Mar; Vol. 10 (2), pp. 172-179.
DOI:	10.4168/aair.2018.10.2.172
Abstrakt:	Purpose: Bisphenol A (BPA) exposure may increase the risk of asthma. Genetic polymorphisms of oxidative stress-related genes, glutathione S-transferases (GSTM1, GSTP1), manganese superoxide dismutase, catalase, myeloperoxidase, and microsomal epoxide hydrolase may be related to BPA exposure. The aim is to evaluate whether oxidative stress genes modulates associations of BPA exposure with asthma. Methods: We conducted a case-control study comprised of 126 asthmatic children and 327 controls. Urine Bisphenol A glucuronide (BPAG) levels were measured by ultra-performance liquid chromatography/tandem mass spectrometry, and genetic variants were analyzed by a TaqMan assay. Information on asthma and environmental exposure was collected. Analyses of variance and logistic regressions were performed to determine the association of genotypes and urine BPAG levels with asthma. Results: BPAG levels were significantly associated with asthma (adjusted odds ratio [aOR], 1.29 per log unit increase in concentration; 95% confidence interval [CI], 1.081.55). Compared to the GG genotype, children with a GSTP1 AA genotype had higher urine BPAG concentrations (geometric mean [standard error], 12.72 [4.16] vs 11.42 [2.82]; P=0.036). In children with high BPAG, the GSTP1 AA genotype was related to a higher odds of asthma than the GG genotype (aOR, 4.84; 95% CI, 1.0223.06). Conclusions: GSTP1 variants are associated with urine BPA metabolite levels. Oxidative stress genes may modulate the effect of BPA exposure on asthma. Competing Interests: There are no financial or other issues that might lead to conflict of interest. (Copyright © 2018 The Korean Academy of Asthma, Allergy and Clinical Immunology · The Korean Academy of Pediatric Allergy and Respiratory Disease)
Databáze:	MEDLINE
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