Andrographolide, a diterpene lactone from Andrographis paniculata and its therapeutic promises in cancer.

Autor: Islam MT; Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, 700000, Vietnam; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, 700000, Vietnam; Department of Pharmacy, Ranada Prasad Shaha University, Narayanganj, 1400, Bangladesh., Ali ES; Gaco Pharmaceuticals and Research Laboratory, Dhaka, 1000, Bangladesh; College of Medicine and Public Health, Flinders University, Bedford Park, Adelaide, 5042, Australia., Uddin SJ; Pharmacy Discipline, School of Life Sciences, Khulna University, Khulna, 9208, Bangladesh., Islam MA; Pharmacy Discipline, School of Life Sciences, Khulna University, Khulna, 9208, Bangladesh., Shaw S; Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA, 02142, USA., Khan IN; Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, 25100, Pakistan., Saravi SSS; Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, USA; Department of Toxicology-Pharmacology, Faculty of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran., Ahmad S; Department of Bio-Sciences, Integral University, Lucknow, U.P., 226026, India., Rehman S; Department of Bio-Sciences, Integral University, Lucknow, U.P., 226026, India., Gupta VK; Department of Chemistry and Biotechnology, Tallinn University of Technology, 12618, Tallinn, Estonia., Găman MA; 'Carol Davila' University of Medicine and Pharmacy, Bucharest, Romania; Facoltà di Medicina e Chirurgia, Università degli Studi di Bari 'Aldo Moro', Bari, Italy., Găman AM; Department of Pathophysiology, Research Center of Experimental and Clinical Medicine, University of Medicine and Pharmacy of Craiova, Romania; Department of Haematology, Filantropia City Hospital of Craiova, Craiova, Romania., Yele S; School of Pharmacy and Technology Management, SVKM's NMIMS, Shirpur, India., Das AK; Pharmacy Discipline, School of Life Sciences, Khulna University, Khulna, 9208, Bangladesh., de Castro E Sousa JM; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil., de Moura Dantas SMM; Department of Biological Sciences, Federal University of Piauí, Teresina, Brazil., Rolim HML; Laboratory of Pharmaceutical Nanosystems (NANOSFAR), Postgraduate Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, Brazil., de Carvalho Melo-Cavalcante AA; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, 64.049-550, Brazil., Mubarak MS; Department of Chemistry, The University of Jordan, Amman, 11942, Jordan., Yarla NS; Department of Animal Biology, School of Life Sciences, University of Hyderabad, Hyderabad, 500003, T.N., India., Shilpi JA; Pharmacy Discipline, School of Life Sciences, Khulna University, Khulna, 9208, Bangladesh., Mishra SK; Cancer Biology Laboratory, School of Biological Sciences (Zoology), Dr. Harisingh Gour Central University, Sagar, 470003, M.P., India., Atanasov AG; Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, Jastrzebiec, Poland; Department of Pharmacognosy, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, A-1090, Vienna, Austria. Electronic address: atanas.atanasov@univie.ac.at., Kamal MA; King Fahd Medical Research Center, King Abdulaziz University, Saudi Arabia; Enzymoics, 7 Peterlee Place, Hebersham, NSW, 2770, Australia; Novel Global Community Educational Foundation, Australia. Electronic address: kamal@gcvu.org.
Jazyk: angličtina
Zdroj: Cancer letters [Cancer Lett] 2018 Apr 28; Vol. 420, pp. 129-145. Date of Electronic Publication: 2018 Feb 14.
DOI: 10.1016/j.canlet.2018.01.074
Abstrakt: The diterpene lactone andrographolide, isolated from Andrographis paniculata, has been proven to possess several important protective biological activities, including antioxidant, anti-inflammatory, immunomodulatory, antiseptic, antimicrobial, cytotoxic, hypolipidemic, cardioprotective, hepatoprotective, and neuroprotective effects. In addition, it has been reported to play a therapeutic role in the treatment of major human diseases, such as Parkinson's disease, rheumatoid arthritis, and colitis. This systematic review aims to highlight andrographolide as a promising agent in cancer treatment. To this purpose, a number of databases were used to search for the cytotoxic/anticancer effects of andrographolide in pre-clinical and clinical studies. Among 1703 identified literature articles, 139 were included in this review; 109 were investigated as non-clinical, whereas 24, 3, and 3 were pre-clinical, clinical, and non-pre-clinical trials, respectively. Among the model systems, cultured cell lines appeared as the most frequently (79.14%) used, followed by in vivo models using rodents, among others. Furthermore, andrographolide was found to exert cytotoxic/anticancer effects on almost all types of cell lines with the underlying mechanisms involving oxidative stress, cell cycle arrest, anti-inflammatory and immune system mediated effects, apoptosis, necrosis, autophagy, inhibition of cell adhesion, proliferation, migration, invasion, anti-angiogenic activity, and other miscellaneous actions. After careful consideration of the relevant evidence, we suggest that andrographolide can be one of the potential agents in the treatment of cancer in the near future.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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