Electrogenic N-methyl-D-aspartate receptor signaling enhances binaural responses in the adult brainstem.

Autor: Siveke I; Division of Neurobiology, Department Biology II, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.; Institute of Zoology and Neurobiology, Ruhr-Universität Bochum, 44780, Bochum, Germany., Ammer JJ; Division of Neurobiology, Department Biology II, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.; Centre for Integrative Physiology, Edinburgh Medical School: Biomedical Sciences, University of Edinburgh, Edinburgh, UK., Gleiss SA; Division of Neurobiology, Department Biology II, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.; Graduate School for Systemic Neurosciences, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany., Grothe B; Division of Neurobiology, Department Biology II, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.; Graduate School for Systemic Neurosciences, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany., Leibold C; Computational Neuroscience, Department Biology II, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany., Felmy F; Division of Neurobiology, Department Biology II, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.; Institute of Zoology, University of Veterinary Medicine Hannover, 30599, Hannover, Germany.
Jazyk: angličtina
Zdroj: The European journal of neuroscience [Eur J Neurosci] 2018 Apr; Vol. 47 (7), pp. 858-865. Date of Electronic Publication: 2018 Feb 21.
DOI: 10.1111/ejn.13859
Abstrakt: In sensory systems, the neuronal representation of external stimuli is enhanced along the sensory pathway. In the auditory system, strong enhancement of binaural information takes place between the brainstem and the midbrain; however, the underlying cellular mechanisms are unknown. Here we investigated the transformation of binaural information in the dorsal nucleus of the lateral lemniscus (DNLL), a nucleus that connects the binaural nuclei in the brainstem and the inferior colliculus in the midbrain. We used in vitro and in vivo electrophysiology in adult Mongolian gerbils to show that N-methyl-D-aspartate receptor (NMDARs) play a critical role in neuronal encoding of stimulus properties in the DNLL. While NMDARs increase firing rates, the timing and the accuracy of the neuronal responses remain unchanged. NMDAR-mediated excitation increases the information about the acoustic stimulus. Taken together, our results show that NMDARs in the DNLL enhance the auditory information content in adult mammal brainstem.
(© 2018 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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