| Autor: |
Durán GM; Department of Analytical Chemistry and Food Technology, University of Castilla-La Mancha, Camilo José Cela Av., Ciudad Real E 13004, Spain.; IRICA (Regional Institute of Applied Scientific Research), Camilo José Cela Av., E 13004 Ciudad Real, Spain., Benavidez TE; Department of Chemistry, Clemson University, 219 Hunter Laboratories, Clemson, SC 29634, USA., Contento AM; Department of Analytical Chemistry and Food Technology, University of Castilla-La Mancha, Camilo José Cela Av., Ciudad Real E 13004, Spain., Ríos A; Department of Analytical Chemistry and Food Technology, University of Castilla-La Mancha, Camilo José Cela Av., Ciudad Real E 13004, Spain., García CD; Department of Chemistry, Clemson University, 219 Hunter Laboratories, Clemson, SC 29634, USA. |
| Abstrakt: |
A simple methodology was developed to quantify penicillamine (PA) in pharmaceutical samples, using the selective interaction of the drug with Cu-modified graphene quantum dots (Cu-GQDs). The proposed strategy combines the advantages of carbon dots (over other nanoparticles) with the high affinity of PA for the proposed Cu-GQDs, resulting in a significant and selective quenching effect. Under the optimum conditions for the interaction, a linear response (in the 0.10-7.50 µmol/L PA concentration range) was observed. The highly fluorescent GQDs used were synthesized using uric acid as single precursor and then characterized by high resolution transmission electron microscopy, Raman spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, fluorescence, and absorption spectroscopy. The proposed methodology could also be extended to other compounds, further expanding the applicability of GQDs. |
