Predictors of therapy failure in newly diagnosed pulmonary tuberculosis cases in Beira, Mozambique.

Autor: Pizzol D; Research Unit, Doctors with Africa-CUAMM, Beira, Mozambique., Veronese N; Department of Medicine (DIMED)-Geriatrics Section, University of Padova, Padua, Italy., Marotta C; Department of Science for Health Promotion and Mother to Child Care 'G. D'Alessandro', University of Palermo, via del Vespro, 133, Palermo, Italy., Di Gennaro F; Department of Infectious Diseases, University of Bari 'Aldo Moro', P.zza G Cesare 3, Bari, Italy. cicciodigennaro@yahoo.it.; Doctors with Africa-CUAMM, Padua, Italy. cicciodigennaro@yahoo.it., Moiane J; Faculty of Health Sciences, Catholic University of Mozambique, Center for Research in Infectious Diseases, Beira, Mozambique., Chhaganlal K; Faculty of Health Sciences, Catholic University of Mozambique, Center for Research in Infectious Diseases, Beira, Mozambique., Monno L; Department of Infectious Diseases, University of Bari 'Aldo Moro', P.zza G Cesare 3, Bari, Italy., Putoto G; Research Section, Doctors with Africa CUAMM, Padua, Italy., Mazzucco W; Department of Science for Health Promotion and Mother to Child Care 'G. D'Alessandro', University of Palermo, via del Vespro, 133, Palermo, Italy., Saracino A; Department of Infectious Diseases, University of Bari 'Aldo Moro', P.zza G Cesare 3, Bari, Italy.
Jazyk: angličtina
Zdroj: BMC research notes [BMC Res Notes] 2018 Feb 05; Vol. 11 (1), pp. 99. Date of Electronic Publication: 2018 Feb 05.
DOI: 10.1186/s13104-018-3209-9
Abstrakt: Objective: Tuberculosis (TB) remains a major global health issue, ranking in the top ten causes of death worldwide. A deep understanding of factors influencing poor treatment outcomes may allow the development of additional treatment strategies, focused on the most vulnerable groups. Aims of the study were: (i) to evaluate the treatment outcome among TB subjects followed in an outpatient setting and (ii) to analyze factors associated with treatment failure in newly diagnosed patients with pulmonary TB in Beira, the second largest city of Mozambique.
Results: A total of 301 TB adult patients (32.6% females) were enrolled. Among them, 62 (20.6%) experienced a treatment failure over a 6 months follow-up. On multivariate model, being males (O.R. = 1.73; 95% CI 1.28-2.15), absence of education (O.R. = 1.85; 95% CI 1.02-2.95), monthly income under 50 dollars (O.R. = 1.74; 95% CI 1.24-2.21) and being employed (O.R. = 1.57; 95% CI 1.21-1.70), low body mass index values (O.R. = 1.42; 95% CI 1.18-1.72) and HIV status (O.R. = 1.42; 95% CI 1.10-1.78) increased the likelihood of therapy failure over 6 months of follow-up. In this study, patients who need more medical attention were young males, malnourished, with low income and low educational degree and HIV positive. These subjects were more likely to fail therapy.
Databáze: MEDLINE
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