Mind the Organelle Gap - Peroxisome Contact Sites in Disease.

Autor: Castro IG; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel., Schuldiner M; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: maya.schuldiner@weizmann.ac.il., Zalckvar E; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: einat.zalckvar@weizmann.ac.il.
Jazyk: angličtina
Zdroj: Trends in biochemical sciences [Trends Biochem Sci] 2018 Mar; Vol. 43 (3), pp. 199-210. Date of Electronic Publication: 2018 Jan 31.
DOI: 10.1016/j.tibs.2018.01.001
Abstrakt: The eukaryotic cell is organized as a complex grid system where membrane-bound cellular compartments, organelles, must be localized to the right place at the right time. One way to facilitate correct organelle localization and organelle cooperation is through membrane contact sites, areas of close proximity between two organelles that are bridged by protein/lipid complexes. It is now clear that all organelles physically contact each other. The main focus of this review is contact sites of peroxisomes, central metabolic hubs whose defects lead to a variety of diseases. New peroxisome contacts, their tethering complexes and functions have been recently discovered. However, if and how peroxisome contacts contribute to the development of peroxisome-related diseases is still a mystery.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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