Effects of Navigated Repetitive Transcranial Magnetic Stimulation After Stroke.

Autor:	Chervyakov AV; Research Center of Neurology, Moscow, Russia., Poydasheva AG; Research Center of Neurology, Moscow, Russia., Lyukmanov RH; Research Center of Neurology, Moscow, Russia., Suponeva NA; Research Center of Neurology, Moscow, Russia., Chernikova LA; Research Center of Neurology, Moscow, Russia., Piradov MA; Research Center of Neurology, Moscow, Russia., Ustinova KI; Department of Physical Therapy, Central Michigan University, Michigan, U.S.A.
Jazyk:	angličtina
Zdroj:	Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society [J Clin Neurophysiol] 2018 Mar; Vol. 35 (2), pp. 166-172.
DOI:	10.1097/WNP.0000000000000456
Abstrakt:	Purpose: The purpose of this study was to test the effects of navigated repetitive transcranial magnetic stimulation, delivered in different modes, on motor impairments and functional limitations after stroke. Methods: The study sample included 42 patients (58.5 ± 10.7 years; 26 males) who experienced a single unilateral stroke (1-12 months previously) in the area of the middle cerebral artery. Patients completed a course of conventional rehabilitation, together with 10 sessions of navigated repetitive transcranial magnetic stimulation or sham stimulation. Stimulation was scheduled five times a week over two consecutive weeks in an inpatient clinical setting. Patients were randomly assigned to one of four groups and received sham stimulation (n = 10), low-frequency (1-Hz) stimulation of the nonaffected hemisphere (n = 11), high-frequency (10-Hz) stimulation of the affected hemisphere (n = 13), or sequential combination of low- and high-frequency stimulations (n = 8). Participants were evaluated before and after stimulation with clinical tests, including the arm and hand section of the Fugl-Meyer Assessment Scale, modified Ashworth Scale of Muscle Spasticity, and Barthel Index of Activities of Daily Living. Results: Participants in the three groups receiving navigated repetitive transcranial magnetic stimulation showed improvements in arm and hand functions on the Fugl-Meyer Stroke Assessment Scale. Ashworth Scale of Muscle Spasticity and Barthel Index scores were significantly reduced in groups receiving low- or high-frequency stimulation alone. Conclusions: Including navigated repetitive transcranial magnetic stimulation in a conventional rehabilitation program positively influenced motor and functional recovery in study participants, demonstrating the clinical potential of the method. The results of this study will be used for designing a large-scale clinical trial.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu