Single institution validation of a modified graded prognostic assessment of patients with breast cancer brain metastases.

Autor:	Tai CH; Department of Radiation Oncology, Columbia University Medical Center, New York, NY 10032, USA., Wu CC; Department of Radiation Oncology, Columbia University Medical Center, New York, NY 10032, USA., Hwang ME; Department of Radiation Oncology, Columbia University Medical Center, New York, NY 10032, USA., Saraf A; Department of Radiation Oncology, Columbia University Medical Center, New York, NY 10032, USA., Grubb C; Department of Radiation Oncology, Columbia University Medical Center, New York, NY 10032, USA., Jani A; Department of Radiation Oncology, Columbia University Medical Center, New York, NY 10032, USA., Lapa ME; Department of Radiation Oncology, Columbia University Medical Center, New York, NY 10032, USA., Andrews JIS; Department of Radiation Oncology, Columbia University Medical Center, New York, NY 10032, USA., Isaacson SR; Department of Radiation Oncology, Columbia University Medical Center, New York, NY 10032, USA.; Department of Neurological Surgery, Columbia University Medical Center, New York, NY 10032, USA., Sonabend AM; Department of Neurological Surgery, Columbia University Medical Center, New York, NY 10032, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA., Sheth SA; Department of Neurological Surgery, Columbia University Medical Center, New York, NY 10032, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA., McKhann GM; Department of Neurological Surgery, Columbia University Medical Center, New York, NY 10032, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA., Sisti MB; Department of Neurological Surgery, Columbia University Medical Center, New York, NY 10032, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA., Bruce JN; Department of Neurological Surgery, Columbia University Medical Center, New York, NY 10032, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA., Cheng SK; Department of Radiation Oncology, Columbia University Medical Center, New York, NY 10032, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA., Connolly EP; Department of Radiation Oncology, Columbia University Medical Center, New York, NY 10032, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA., Wang TJ; Department of Radiation Oncology, Columbia University Medical Center, New York, NY 10032, USA.; Department of Neurological Surgery, Columbia University Medical Center, New York, NY 10032, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
Jazyk:	angličtina
Zdroj:	CNS oncology [CNS Oncol] 2018 Jan; Vol. 7 (1), pp. 25-34. Date of Electronic Publication: 2018 Feb 02.
DOI:	10.2217/cns-2017-0023
Abstrakt:	Aim: The number of breast cancer brain metastases is a prognostic clinical variable in the modified graded prognostic assessment (GPA) Index for breast cancer. Patients & Methods: We retrospectively gathered data from 127 breast cancer patients who underwent radiation therapy for brain metastasis. Patients were stratified by both breast GPA and modified breast GPA scores, and survival was determined using the Kaplan-Meier curves and Cox proportional hazards model. Results & Conclusion: The Kaplan-Meier curve for patients under the breast GPA classification were not significant, but were significant under the modified breast GPA classification. The inclusion of number of brain metastases into the modified breast GPA index improved prognosis, thus validating the use of the modified breast GPA in prognosticating patient outcome.
Databáze:	MEDLINE
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