Effects of Increased Arterial Stiffness on Atherosclerotic Plaque Amounts.

Autor:	Stoka KV; Department of Mechanical Engineering and Materials Science, Washington University, St. Louis, MO 63130., Maedeker JA; Department of Mechanical Engineering and Materials Science, Washington University, St. Louis, MO 63130., Bennett L; Department of Biomedical Engineering, Saint Louis University, St. Louis, MO 63130., Bhayani SA; Department of Biomedical Engineering, Saint Louis University, St. Louis, MO 63130., Gardner WS; Department of Biomedical Engineering, Saint Louis University, St. Louis, MO 63130., Procknow JD; Department of Mechanical Engineering and Materials Science, Washington University, St. Louis, MO 63130., Cocciolone AJ; Department of Mechanical Engineering and Materials Science, Washington University, , St. Louis, MO 63130., Walji TA; Department of Cell Biology and Physiology, Washington University, St. Louis, MO 63130., Craft CS; Department of Cell Biology and Physiology, Washington University, St. Louis, MO 63130., Wagenseil JE; Department of Mechanical Engineering and Materials Science, Washington University, , St. Louis, MO 63130 e-mail: .
Jazyk:	angličtina
Zdroj:	Journal of biomechanical engineering [J Biomech Eng] 2018 May 01; Vol. 140 (5).
DOI:	10.1115/1.4039175
Abstrakt:	Increased arterial stiffness is associated with atherosclerosis in humans, but there have been limited animal studies investigating the relationship between these factors. We bred elastin wildtype (Eln+/+) and heterozygous (Eln+/-) mice to apolipoprotein E wildtype (Apoe+/+) and knockout (Apoe-/-) mice and fed them normal diet (ND) or Western diet (WD) for 12 weeks. Eln+/- mice have increased arterial stiffness. Apoe-/- mice develop atherosclerosis on ND that is accelerated by WD. It has been reported that Apoe-/- mice have increased arterial stiffness and that the increased stiffness may play a role in atherosclerotic plaque progression. We found that Eln+/+Apoe-/- arterial stiffness is similar to Eln+/+Apoe+/+ mice at physiologic pressures, suggesting that changes in stiffness do not play a role in atherosclerotic plaque progression in Apoe-/- mice. We found that Eln+/-Apoe-/- mice have increased structural arterial stiffness compared to Eln+/+Apoe-/- mice, but they only have increased amounts of ascending aortic plaque on ND, not WD. The results suggest a change in atherosclerosis progression but not end stage disease in Eln+/-Apoe-/- mice due to increased arterial stiffness. Possible contributing factors include increased blood pressure and changes in circulating levels of interleukin-6 (IL6) and transforming growth factor beta 1 (TGF-β1) that are also associated with Eln+/- genotype.
Databáze:	MEDLINE
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