24-month HIV-free survival among infants born to HIV-positive women enrolled in Option B+ program in Kigali, Rwanda: The Kabeho Study.

Autor:	Gill MM; Elizabeth Glaser Pediatric AIDS Foundation Department of Epidemiology and Biostatistics, Milken Institute School of Public Health, The George Washington University, Washington, DC Rwanda Biomedical Center/Ministry of Health Rwanda University Teaching Hospitals (CHU), Kigali, Rwanda., Hoffman HJ, Ndatimana D, Mugwaneza P, Guay L, Ndayisaba GF, Bobrow EA, Asiimwe A, Mofenson LM
Jazyk:	angličtina
Zdroj:	Medicine [Medicine (Baltimore)] 2017 Dec; Vol. 96 (51), pp. e9445.
DOI:	10.1097/MD.0000000000009445
Abstrakt:	Lifelong antiretroviral therapy (ART) provision to all pregnant HIV-positive women ("Option B+") has been recommended by the World Health Organization since 2013, but there remain limited data on the effects of Option B+ on long-term HIV-free survival in breastfeeding HIV-exposed infants. The Kigali Antiretroviral and Breastfeeding Assessment for the Elimination of HIV (Kabeho) study enrolled HIV-positive women from the third trimester of pregnancy to 2 weeks postpartum in 14 heath facilities implementing Option B+ in Kigali, Rwanda. Mother-child pairs in the longitudinal observational cohort were followed until 24 months postpartum, with HIV diagnostic testing at 6 weeks, and 9, 18 and 24 months. The Kaplan-Meier method was used to estimate HIV transmission, survival, and HIV-free survival through 24 months. We enrolled 608 HIV-positive women in 2013-2014; birth outcome data were available for 600 women and 597 live-born infants. By 6 weeks, 11 infants had died and 3 infants had confirmed HIV infection (0.5% transmission; 95% confidence interval [CI] 0.2-1.6). At 9 months, there were 9 additional deaths and 2 new infections (cumulative transmission 0.9%, 95% CI 0.4-2.2). At 18 months, there were 6 additional deaths and no new infant infections. At 24 months, there were no additional child deaths and 1 new infection (cumulative 2.2%, 95% CI 0.7-7.0), for an overall 24-month HIV-free survival of 93.2% (95% CI 89.5-95.6). Low transmission rates and high HIV-free survival at 24 months were achieved in breastfeeding infants of HIV-positive mothers receiving universal ART in urban health facilities in Rwanda, though vigilance on maintaining viral suppression for ART-experienced women is needed. (Copyright © 2017 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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