Comparison of retinal vascular geometry in obese and non-obese children.

Autor: Tai ELM; Department of Ophthalmology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.; Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia., Kueh YC; Unit of Biostatistics & Research Methodology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia., Wan Hitam WH; Department of Ophthalmology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.; Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia., Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; DUKE-NUS Medical School, Singapore, Singapore.; Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia., Shatriah I; Department of Ophthalmology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.; Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2018 Feb 01; Vol. 13 (2), pp. e0191434. Date of Electronic Publication: 2018 Feb 01 (Print Publication: 2018).
DOI: 10.1371/journal.pone.0191434
Abstrakt: Purpose: Childhood obesity is associated with adult cardiometabolic disease. We postulate that the underlying microvascular dysfunction begins in childhood. We thus aimed to compare retinal vascular parameters between obese and non-obese children.
Methods: This was a cross-sectional study involving 166 children aged 6 to 12 years old in Malaysia. Ocular examination, biometry, retinal photography, blood pressure and body mass index measurement were performed. Participants were divided into two groups; obese and non-obese. Retinal vascular parameters were measured using validated software.
Results: Mean age was 9.58 years. Approximately 51.2% were obese. Obese children had significantly narrower retinal arteriolar caliber (F(1,159) = 6.862, p = 0.010), lower arteriovenous ratio (F(1,159) = 17.412, p < 0.001), higher venular fractal dimension (F(1,159) = 4.313, p = 0.039) and higher venular curvature tortuosity (F(1,158) = 5.166, p = 0.024) than non-obese children, after adjustment for age, gender, blood pressure and axial length.
Conclusions: Obese children have abnormal retinal vascular geometry. These findings suggest that childhood obesity is characterized by early microvascular abnormalities that precede development of overt disease. Further research is warranted to determine if these parameters represent viable biomarkers for risk stratification in obesity.
Databáze: MEDLINE
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