High brain serotonin levels in migraine between attacks: A 5-HT 4 receptor binding PET study.

Autor: Deen M; Danish Headache Center, Department of Neurology, Rigshospitalet, DK-2600 Glostrup, Denmark; Neurobiology Research Unit and NeuroPharm, Department of Neurology, Rigshospitalet, DK-2100 Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark; Department of Neurology, Rigshospitalet, DK-2100 Copenhagen, Denmark; Center for Experimental Medicine Neuropharmacology, Department of Neurology, Rigshospitalet, DK-2100 Copenhagen, Denmark., Hansen HD; Neurobiology Research Unit and NeuroPharm, Department of Neurology, Rigshospitalet, DK-2100 Copenhagen, Denmark; Center for Experimental Medicine Neuropharmacology, Department of Neurology, Rigshospitalet, DK-2100 Copenhagen, Denmark., Hougaard A; Danish Headache Center, Department of Neurology, Rigshospitalet, DK-2600 Glostrup, Denmark; Department of Neurology, Rigshospitalet, DK-2100 Copenhagen, Denmark., Nørgaard M; Neurobiology Research Unit and NeuroPharm, Department of Neurology, Rigshospitalet, DK-2100 Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark; Center for Experimental Medicine Neuropharmacology, Department of Neurology, Rigshospitalet, DK-2100 Copenhagen, Denmark., Eiberg H; Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark., Lehel S; PET- and Cyclotron Unit, Rigshospitalet, DK-2100 Copenhagen, Denmark., Ashina M; Danish Headache Center, Department of Neurology, Rigshospitalet, DK-2600 Glostrup, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark; Department of Neurology, Rigshospitalet, DK-2100 Copenhagen, Denmark., Knudsen GM; Neurobiology Research Unit and NeuroPharm, Department of Neurology, Rigshospitalet, DK-2100 Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark; Center for Experimental Medicine Neuropharmacology, Department of Neurology, Rigshospitalet, DK-2100 Copenhagen, Denmark. Electronic address: gitte@nru.dk.
Jazyk: angličtina
Zdroj: NeuroImage. Clinical [Neuroimage Clin] 2018 Jan 28; Vol. 18, pp. 97-102. Date of Electronic Publication: 2018 Jan 28 (Print Publication: 2018).
DOI: 10.1016/j.nicl.2018.01.016
Abstrakt: Migraine has been hypothesized to be a syndrome of chronic low serotonin (5-HT) levels, but investigations of brain 5-HT levels have given equivocal results. Here, we used positron emission tomography (PET) imaging of the 5-HT 4 receptor as a proxy for brain 5-HT levels. Given that the 5-HT 4 receptor is inversely related to brain 5-HT levels, we hypothesized that between attacks migraine patients would have higher 5-HT 4 receptor binding compared to controls. Eighteen migraine patients without aura (migraine free >48 h), and 16 age- and sex-matched controls underwent PET scans after injection of [ 11 C]SB207145, a specific 5-HT 4 receptor radioligand. An investigator blinded to group calculated a neocortical mean [ 11 C]SB207145 binding potential (BP ND ). Three migraine patients reported a migraine attack within 48 h after the scan and were excluded from the primary analysis. Comparing 15 migraine patients and 16 controls, we found that migraine patients have significantly lower neocortical 5-HT 4 receptor binding than controls (0.60 ± 0.09 vs. 0.67 ± 0.05, p = .024), corrected for 5-HTTLPR genotype, sex and age. We found no association between 5-HT 4 receptor binding and attack frequency, years with migraine or time since last migraine attack. Our finding of lower 5-HT 4 receptor binding in migraine patients is suggestive of higher brain 5-HT levels. This is in contrast with the current belief that migraine is associated with low brain 5-HT levels. High brain 5-HT levels may represent a trait of the migraine brain or it could be a consequence of migraine attacks.
Databáze: MEDLINE
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