Weak Directing Group Steered Formal Oxidative [2+2+2]-Cyclization for Selective Benzannulation of Indoles.
| Autor: | Bettadapur KR; Department of Organic Chemistry, Indian Institute of Science , Bangalore 560 012, Karnataka India., Kapanaiah R; Department of Organic Chemistry, Indian Institute of Science , Bangalore 560 012, Karnataka India., Lanke V; Department of Organic Chemistry, Indian Institute of Science , Bangalore 560 012, Karnataka India., Prabhu KR; Department of Organic Chemistry, Indian Institute of Science , Bangalore 560 012, Karnataka India. |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of organic chemistry [J Org Chem] 2018 Feb 16; Vol. 83 (4), pp. 1810-1818. Date of Electronic Publication: 2018 Jan 31. |
| DOI: | 10.1021/acs.joc.7b02719 |
| Abstrakt: | A double C-H activation and double insertion process to achieve the synthesis benzo[e]indole frameworks has been disclosed. This type of benzannulation is directed by a trifluoromethylketone moiety, which is easy to install on the indole C3-position. Overall the reaction takes places as an oxidative cyclization of two alkynes with the C4-C5 position of indole. |
| Databáze: | MEDLINE |
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