Contextual control of skin immunity and inflammation by Corynebacterium .

Autor:	Ridaura VK; Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD., Bouladoux N; Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.; Microbiome Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD., Claesen J; Department of Bioengineering, Stanford University, Stanford, CA., Chen YE; Department of Bioengineering, Stanford University, Stanford, CA., Byrd AL; Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.; Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD.; Department of Bioinformatics, Boston University, Boston, MA., Constantinides MG; Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD., Merrill ED; Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD., Tamoutounour S; Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD., Fischbach MA; Department of Bioengineering, Stanford University, Stanford, CA fischbach@fischbachgroup.org., Belkaid Y; Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD ybelkaid@niaid.nih.gov.; Microbiome Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
Jazyk:	angličtina
Zdroj:	The Journal of experimental medicine [J Exp Med] 2018 Mar 05; Vol. 215 (3), pp. 785-799. Date of Electronic Publication: 2018 Jan 30.
DOI:	10.1084/jem.20171079
Abstrakt:	How defined microbes influence the skin immune system remains poorly understood. Here we demonstrate that Corynebacteria , dominant members of the skin microbiota, promote a dramatic increase in the number and activation of a defined subset of γδ T cells. This effect is long-lasting, occurs independently of other microbes, and is, in part, mediated by interleukin (IL)-23. Under steady-state conditions, the impact of Corynebacterium is discrete and noninflammatory. However, when applied to the skin of a host fed a high-fat diet, Corynebacterium accolens alone promotes inflammation in an IL-23-dependent manner. Such effect is highly conserved among species of Corynebacterium and dependent on the expression of a dominant component of the cell envelope, mycolic acid. Our data uncover a mode of communication between the immune system and a dominant genus of the skin microbiota and reveal that the functional impact of canonical skin microbial determinants is contextually controlled by the inflammatory and metabolic state of the host. (© 2018 Ridaura et al.)
Databáze:	MEDLINE
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