Ocular and uteroplacental pathology in a macaque pregnancy with congenital Zika virus infection.

Autor: Mohr EL; Department of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Block LN; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Newman CM; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Stewart LM; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Koenig M; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Semler M; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Breitbach ME; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Teixeira LBC; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Zeng X; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, United States of America., Weiler AM; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Barry GL; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Thoong TH; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Wiepz GJ; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Dudley DM; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Simmons HA; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Mejia A; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Morgan TK; Departments of Pathology and Obstetrics & Gynecology, Oregon Health & Science University, Portland, Oregon, United States of America., Salamat MS; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Kohn S; Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Antony KM; Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Aliota MT; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Mohns MS; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Hayes JM; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Schultz-Darken N; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Schotzko ML; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Peterson E; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Capuano S 3rd; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Osorio JE; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., O'Connor SL; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Friedrich TC; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., O'Connor DH; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Golos TG; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.; Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2018 Jan 30; Vol. 13 (1), pp. e0190617. Date of Electronic Publication: 2018 Jan 30 (Print Publication: 2018).
DOI: 10.1371/journal.pone.0190617
Abstrakt: Congenital Zika virus (ZIKV) infection impacts fetal development and pregnancy outcomes. We infected a pregnant rhesus macaque with a Puerto Rican ZIKV isolate in the first trimester. The pregnancy was complicated by preterm premature rupture of membranes (PPROM), intraamniotic bacterial infection and fetal demise 49 days post infection (gestational day 95). Significant pathology at the maternal-fetal interface included acute chorioamnionitis, placental infarcts, and leukocytoclastic vasculitis of the myometrial radial arteries. ZIKV RNA was disseminated throughout fetal tissues and maternal immune system tissues at necropsy, as assessed by quantitative RT-PCR for viral RNA. Replicating ZIKV was identified in fetal tissues, maternal uterus, and maternal spleen by fluorescent in situ hybridization for viral replication intermediates. Fetal ocular pathology included a choroidal coloboma, suspected anterior segment dysgenesis, and a dysplastic retina. This is the first report of ocular pathology and prolonged viral replication in both maternal and fetal tissues following congenital ZIKV infection in a rhesus macaque. PPROM followed by fetal demise and severe pathology of the visual system have not been described in macaque congenital ZIKV infection previously. While this case of ZIKV infection during pregnancy was complicated by bacterial infection with PPROM, the role of ZIKV on this outcome cannot be precisely defined, and further nonhuman primate studies will determine if increased risk for PPROM or other adverse pregnancy outcomes are associated with congenital ZIKV infection.
Databáze: MEDLINE
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