A novel treatment approach to infected nonunion of long bones without systemic antibiotics.

Autor: Masrouha KZ; Department of Surgery, Orthopedics Division, American University of Beirut Medical Center, P. O. Box 11-0236, Riad El-Solh, Beirut, 1107 2020, Lebanon., Raad ME; Department of Surgery, Orthopedics Division, American University of Beirut Medical Center, P. O. Box 11-0236, Riad El-Solh, Beirut, 1107 2020, Lebanon., Saghieh SS; Department of Surgery, Orthopedics Division, American University of Beirut Medical Center, P. O. Box 11-0236, Riad El-Solh, Beirut, 1107 2020, Lebanon. ss15@aub.edu.lb.
Jazyk: angličtina
Zdroj: Strategies in trauma and limb reconstruction [Strategies Trauma Limb Reconstr] 2018 Apr; Vol. 13 (1), pp. 13-18. Date of Electronic Publication: 2018 Jan 29.
DOI: 10.1007/s11751-018-0303-4
Abstrakt: Infected nonunion of long bones may require intravenous antibiotics over a lengthy period which may result in a high rate of complications. This study aims to assess the efficacy of local antibiotics used as a replacement to prolonged intravenous therapy. Thirteen patients with infected nonunion of long bones who failed at least one previous surgery were included. The infection was treated through extensive debridement, application of antibiotic-impregnated calcium sulphate pellets and the bone stabilized with external fixation. These patients were monitored for union and infection by clinical signs, laboratory values, and radiographs over a period of 24 months. The results support an eradication of infection and union in all patients with no antibiotic-associated complications. Local antibiotic delivery using calcium sulphate pellets provides an effective method for treatment of nonunion in long bones and is free of the complications from the intravenous route.
Databáze: MEDLINE
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