Towards multi-phase postmortem CT angiography in children: a study on a porcine model.

Autor: Mokrane FZ; Radiology Department, Rangueil University Hospital, 1 Avenue du Professeur Jean Poulhes, 31059 cedex, Toulouse, France. mokrane_fatimazohra@yahoo.fr.; French National Center for Scientific Research, AMIS Laboratory: University of Toulouse, UMR 5288, 37 allées Jules Guesde, 31073, Toulouse, France. mokrane_fatimazohra@yahoo.fr., Dercle L; Gustave Roussy Institute, Université Paris-Saclay, F-94805, Villejuif, France.; New York Presbyterian Hospital, Columbia University, New York, NY, 10039, USA., Meyrignac O; Radiology Department, Rangueil University Hospital, 1 Avenue du Professeur Jean Poulhes, 31059 cedex, Toulouse, France., Crubézy É; French National Center for Scientific Research, AMIS Laboratory: University of Toulouse, UMR 5288, 37 allées Jules Guesde, 31073, Toulouse, France., Rousseau H; Radiology Department, Rangueil University Hospital, 1 Avenue du Professeur Jean Poulhes, 31059 cedex, Toulouse, France., Telmon N; French National Center for Scientific Research, AMIS Laboratory: University of Toulouse, UMR 5288, 37 allées Jules Guesde, 31073, Toulouse, France.; Forensic Department, Rangueil University Hospital, 1 avenue du Professeur Jean Poulhes. 31059 cedex, Toulouse, France., Dedouit F; French National Center for Scientific Research, AMIS Laboratory: University of Toulouse, UMR 5288, 37 allées Jules Guesde, 31073, Toulouse, France.; Unit of Forensic and Anthropological Imaging, Centre universitaire romand de médecine légale (CURML), Chemin de la Vulliette 4, CH-1000, Lausanne 25, Switzerland.
Jazyk: angličtina
Zdroj: International journal of legal medicine [Int J Legal Med] 2018 Sep; Vol. 132 (5), pp. 1391-1403. Date of Electronic Publication: 2018 Jan 30.
DOI: 10.1007/s00414-018-1783-y
Abstrakt: Purpose: Multi-phase postmortem computed tomography angiography (MPMCTA) is a growing technique, which is standardized for adults. Application of this protocol for a children population is not so well defined. Our study aims to adapt the adult's protocol to children, using a porcine model.
Material and Methods: Three groups of 18 pigs were studied, with a weight distribution between 4 and 48 kg. Different pump devices were used. Pigs of group I were studied using the Virtangio® machine, whereas pigs of groups II and III were studied using used the Medrad® machine. Study of vascular opacification was possible using a semi-quantitative method based on 26 arterial and 26 venous segments that were distributed over the entire body from the cephalic extremity to the posterior pawns.
Results: While thoracic, abdominal, and pelvic vascular opacification were complete for each individual pig in a group, group III showed better vascular opacification for the cephalic extremity. This was also true for anterior and posterior pawns vascular opacification. Spearman correlation tests showed a significant relationship between anthropometric characteristics of pigs, injection parameters, and percentage of opacified segments. A higher percentage of opacification was obtained for individuals of lower weights, with comparatively lower quantities of contrast agent injected.
Conclusion: Postmortem computed tomography angiography (PMCTA) was possible for all the individuals, particularly for small weights (4 kg) using the Medrad® machine. However, further studies are needed to better understand the procedure.
Databáze: MEDLINE
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