| Autor: |
Siebra ALA; Laboratory of Pharmacology and Molecular Chemistry and Laboratory of Pharmacology of Natural Products, Center of Biological Sciences and Health, Regional University of Cariri, Crato, CE, Brazil., Oliveira LR; Laboratory of Pharmacology and Molecular Chemistry and Laboratory of Pharmacology of Natural Products, Center of Biological Sciences and Health, Regional University of Cariri, Crato, CE, Brazil., Martins AOBPB; Laboratory of Pharmacology and Molecular Chemistry and Laboratory of Pharmacology of Natural Products, Center of Biological Sciences and Health, Regional University of Cariri, Crato, CE, Brazil., Siebra DC; Federal University of Ceará, Campus Cariri, Barbalha, CE, Brazil., Albuquerque RS; Laboratory of Microbiology and Molecular Biology, Regional University of Cariri, Crato, CE, Brazil., Lemos ICS; Laboratory of Pharmacology and Molecular Chemistry and Laboratory of Pharmacology of Natural Products, Center of Biological Sciences and Health, Regional University of Cariri, Crato, CE, Brazil., Delmondes GA; Laboratory of Pharmacology and Molecular Chemistry and Laboratory of Pharmacology of Natural Products, Center of Biological Sciences and Health, Regional University of Cariri, Crato, CE, Brazil., Tintino SR; Laboratory of Microbiology and Molecular Biology, Regional University of Cariri, Crato, CE, Brazil., Figueredo FG; Laboratory of Microbiology and Molecular Biology, Regional University of Cariri, Crato, CE, Brazil., da Costa JGM; Laboratory of Research in Natural Products, Center of Biological Sciences and Health, University of the Region of Cariri, Crato, CE, Brazil., Coutinho HDM; Laboratory of Microbiology and Molecular Biology, Regional University of Cariri, Crato, CE, Brazil., Menezes IRA; Laboratory of Pharmacology and Molecular Chemistry and Laboratory of Pharmacology of Natural Products, Center of Biological Sciences and Health, Regional University of Cariri, Crato, CE, Brazil., Felipe CFB; Laboratory of Pharmacology and Molecular Chemistry and Laboratory of Pharmacology of Natural Products, Center of Biological Sciences and Health, Regional University of Cariri, Crato, CE, Brazil., Kerntopf MR; Laboratory of Pharmacology and Molecular Chemistry and Laboratory of Pharmacology of Natural Products, Center of Biological Sciences and Health, Regional University of Cariri, Crato, CE, Brazil. |
| Abstrakt: |
The development of new drugs from plants is an interesting alternative approach to overcoming microbial resistance. Passiflora cincinnata shows resistance to diseases and pests and a higher concentration of chemical components that may be useful in the pharmaceutical industry. We investigated the potential antimicrobial and antibiotic-modifying activity of hydroalcoholic extracts of leaves, stems, bark, pulp and seeds of P. cincinnata . The extracts were prepared by homogenization of material in 50% ethanol. Minimum inhibitory concentration (MIC) was determined by the broth dilution method, and the bacterial strains tested were Staphylococcus aureus and Escherichia coli . Antibiotic-modifying activity was evaluated against the strains S. aureus 03 and E. coli 08, using a subinhibitory concentration of extract. The antibiotics tested were: amikacin, gentamicin, ampicillin, potassium benzylpenicillin and oxacillin. The extracts did not show antimicrobial activity of clinical relevance, where the MIC was equal to or greater than 1024 μg/mL. S. aureus showed 13 events, while E. coli showed only 4 events. Among these events, 14 involved synergistic activity, potentiating the effect of the antibiotics, and only 3 events demonstrated antagonistic activity toward ampicillin. Hydroalcoholic extracts are potential antimicrobial agents when combined with conventional drugs little utilized in in vivo treatment. |
