| Autor: |
Caixeta DC; Institute of Biotechnology, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil., Teixeira RR; Institute of Biotechnology, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil., Peixoto LG; Institute of Biotechnology, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil., Machado HL; Institute of Biotechnology, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil., Baptista NB; Institute of Biotechnology, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil., de Souza AV; Institute of Biotechnology, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil., Vilela DD; Institute of Biotechnology, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil., Franci CR; Department of Physiology, University of São Paulo, Ribeirão Preto, Minas Gerais, Brazil., Salmen Espindola F; Institute of Biotechnology, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil. |
| Abstrakt: |
Restraint and cold stress increase both corticosterone and glycemia, which lead to oxidative damages in hepatic tissue. This study assessed the effect of royal jelly (RJ) supplementation on the corticosterone level, glycemia, plasma enzymes and hepatic antioxidant system in restraint and cold stressed rats. Wistar rats were allocated into no-stress, stress, no-stress supplemented with RJ and stress supplemented with RJ groups. Initially, RJ (200mg/Kg) was administered for fourteen days and stressed groups were submitted to chronic stress from the seventh day. The results showed that RJ supplementation decreases corticosterone levels and improves glycemia control after stress induction. RJ supplementation also decreased the body weight, AST, ALP and GGT. Moreover, RJ improved total antioxidant capacity, SOD activity and reduced GSH, GR and lipoperoxidation in the liver. Thus, RJ supplementation reestablished the corticosterone levels and the hepatic antioxidant system in stressed rats, indicating an adaptogenic and hepatoprotective potential of RJ. |
