Evaluation of HPV DNA positivity in colorectal cancer patients in Kerman, Southeast Iran

Autor:	Malekpour Afshar R; Pathology and Stem Cell Research center, Kerman University of Medical Sciences, Kerman, Iran. Email: hamid2008kmu@gmail.com, Deldar Z, Mollaei HR, Arabzadeh SA, Iranpour M
Jazyk:	angličtina
Zdroj:	Asian Pacific journal of cancer prevention : APJCP [Asian Pac J Cancer Prev] 2018 Jan 27; Vol. 19 (1), pp. 193-198. Date of Electronic Publication: 2018 Jan 27.
DOI:	10.22034/APJCP.2018.19.1.193
Abstrakt:	Background: The HPV virus is known to be oncogenic and associations with many cancers has been proven. Although many studies have been conducted on the possible relationship with colorectal cancer (CRC), a definitive role of the virus has yet to be identified. Method: In this cross-sectional study, the frequency of HPV positivity in CRC samples in Kerman was assessed in 84 cases with a mean age of 47.7 ± 12.5 years over two years. Qualitative real time PCR was performed using general primers for the L1 region of HPV DNA. Results: Out of 84 CRC samples, 19 (22.6%), proved positive for HPV DNA. Genotyping of positive samples showed all of these to be of high risk HPV type. Prevalence of HPV infection appears to depend geographic region, life style, diet and other factors. Conclusion: In our location frequency of CRC is low, and this limited the sample size for evaluation of HPV DNA. The most prevalent types were HPV types 51 and 56. While HPV infection may play an important role in colorectal carcinogenesis, this needs to be assessed in future studies. (Creative Commons Attribution License)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu