A continuing challenge: N-heterocyclic carbene-catalyzed syntheses of γ-butyrolactones.

Autor: Murauski KJR; Department of Chemistry, Department of Pharmacology, Center for Molecular Innovation and Drug Discovery, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA. scheidt@northwestern.edu., Jaworski AA, Scheidt KA
Jazyk: angličtina
Zdroj: Chemical Society reviews [Chem Soc Rev] 2018 Mar 05; Vol. 47 (5), pp. 1773-1782.
DOI: 10.1039/c7cs00386b
Abstrakt: Catalytic, stereoselective N-heterocyclic carbene-catalyzed reactions facilitate efficient construction of many different heterocyclic compounds, such as the enantioenriched 5-membered (γ) lactones highlighted in this tutorial review. Herein, various strategies to enable formal [3+2] type annulations between electrophilic carbonyl equivalents and homoenolate nucleophiles for the synthesis of γ-lactones are summarized.
Databáze: MEDLINE