Effects of Multivitamin, Multimineral and Phytonutrient Supplementation on Nutrient Status and Biomarkers of Heart Health Risk in a Russian Population: A Randomized, Double Blind, Placebo Controlled Study.

Autor:	Isakov VA; Institute of Nutrition, Ustinsky Proezd, 2/14, Moscow 109240, Russia. vasily.isakov@gmail.com., Bogdanova AA; Institute of Nutrition, Ustinsky Proezd, 2/14, Moscow 109240, Russia. alex.golubeva@gmail.com., Bessonov VV; Institute of Nutrition, Ustinsky Proezd, 2/14, Moscow 109240, Russia. bessonov@ion.ru., Sentsova TB; Institute of Nutrition, Ustinsky Proezd, 2/14, Moscow 109240, Russia. bio45@inbox.ru., Tutelyan VA; Institute of Nutrition, Ustinsky Proezd, 2/14, Moscow 109240, Russia. tutelyan@ion.ru., Lin Y; Access Business Group International, LLC, 5600 Beach Blvd., Buena Park, CA 90621, USA. ylin@yumeiconsulting.com., Kazlova V; Access Business Group International, LLC, 5600 Beach Blvd., Buena Park, CA 90621, USA. valentina.kazlova@amway.com., Hong J; Access Business Group International, LLC, 5600 Beach Blvd., Buena Park, CA 90621, USA. jina.hong@amway.com., Velliquette RA; Access Business Group International, LLC, 5600 Beach Blvd., Buena Park, CA 90621, USA. rod.velliquette@amway.com.
Jazyk:	angličtina
Zdroj:	Nutrients [Nutrients] 2018 Jan 25; Vol. 10 (2). Date of Electronic Publication: 2018 Jan 25.
DOI:	10.3390/nu10020120
Abstrakt:	The primary objective of this clinical study was to evaluate the effect of a dietary multivitamin, multimineral and phytonutrient (VMP) supplement on blood nutrient status and biomarkers of heart health risk in a Russian population. One hundred twenty healthy adults (40-70 years) were recruited for a 56-day (eight-week) randomized, double blind, placebo controlled study with parallel design. Subjects were divided into two groups and received either a VMP or a placebo (PLA) supplement. Blood nutrient levels of β-carotene, α-tocopherol, vitamin C, B6, B12, red blood cell (RBC) folate, Zinc and Selenium were measured at baseline and on Days 28 and 56, and quercetin was measured at baseline and on Day 56. Blood biomarkers of heart health, i.e. homocysteine (Hcy), high-sensitivity C-reactive protein (hs-CRP), oxidized LDL (ox-LDL), gamma-glutamyl transferase (GGT), uric acid and blood lipid profile, were measured at baseline and Day 56. Dietary VMP supplementation for 56 days significantly increased circulating levels of quercetin, vitamin C, RBC folate and partially prevented the decline in vitamin B6 and B12 status. Both serum Hcy and GGT were significantly reduced (-3.97 ± 10.09 µmol/L; -1.68 ± 14.53 U/L, respectively) after VMP supplementation compared to baseline. Dietary VMP supplementation improved the nutrient status and reduced biomarkers of heart health risk in a Russian population. Competing Interests: The source of funding was Access Business Group International, LLC. Y.L. was an employee of Access Business Group International, LLC during the conduction of this study, V.K., J.H. and R.A.V. are employees of Access Business Group International, LLC. V.A.I., A.A.G., V.V.B., T.B.S. and V.A.T. declare no conflict of interest.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu