Effect of Lorcaserin Alone and in Combination with Phentermine on Food Cravings After 12-Week Treatment: A Randomized Substudy.

Autor: Rebello CJ; Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA., Nikonova EV; Eisai Medical and Scientific Affairs, Eisai Inc., Woodcliff Lake, New Jersey, USA., Zhou S; Eisai Medical and Scientific Affairs, Eisai Inc., Woodcliff Lake, New Jersey, USA., Aronne LJ; Department of Medicine, Weill Cornell Medical College, New York, New York, USA., Fujioka K; Department of Diabetes and Endocrinology, Scripps Clinic, La Jolla, California, USA., Garvey WT; Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA.; Birmingham VA Medical Center, Birmingham, Alabama, USA., Smith SR; Center for the Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida, USA.; Translational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, Florida, USA., Coulter AA; Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA., Greenway FL; Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA.
Jazyk: angličtina
Zdroj: Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2018 Feb; Vol. 26 (2), pp. 332-339.
DOI: 10.1002/oby.22094
Abstrakt: Objective: This study evaluated the effect of lorcaserin 10 mg twice daily (LOR BID), or with phentermine 15 mg once daily (LOR BID + PHEN QD) and 15 mg twice daily (LOR BID + PHEN BID), in conjunction with energy restriction on food cravings.
Methods: Two hundred and thirty-five patients without diabetes but with obesity or overweight and ≥ 1 comorbidity received LOR BID, LOR BID + PHEN QD, or LOR BID + PHEN BID for 12 weeks in a randomized double-blind study. The Food Craving Inventory (FCI) and the Control of Eating Questionnaire (COEQ) were administered over 12 weeks.
Results: The FCI total score and the subscale scores reduced from baseline in all groups. The least squares means (95% confidence intervals) for the total scores were -0.65 (-0.75 to -0.55), -0.75 (-0.84 to -0.65), and -0.84 (-0.95 to -0.74) in the LOR BID, LOR BID + PHEN QD, and LOR BID + PHEN BID groups, respectively. Cravings assessed by COEQ reduced from baseline in all groups. In general, the combination treatments were more effective than lorcaserin alone. At week 12, except for fruit juice and dairy products, general and specific cravings reduced in LOR BID + PHEN BID compared with LOR BID (P < 0.05).
Conclusions: Lorcaserin in combination with phentermine improves control of food cravings during short-term energy restriction.
(© 2018 The Obesity Society.)
Databáze: MEDLINE
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