Influence of Interleukin-6 (174G/C) Gene Polymorphism on Obesity in Egyptian Children.

Autor:	Ibrahim OM; Child Health Department, Medical Division, National Research Centre, Egypt., Gabre AA; Child Health Department, Medical Division, National Research Centre, Egypt., Sallam SF; Child Health Department, Medical Division, National Research Centre, Egypt., El-Alameey IR; Child Health Department, Medical Division, National Research Centre, Egypt., Sabry RN; Child Health Department, Medical Division, National Research Centre, Egypt., Galal EM; Child Health Department, Medical Division, National Research Centre, Egypt., Tawfik SM; Child Health Department, Medical Division, National Research Centre, Egypt., Zarouk WA; Molecular Genetics & Enzymology Department , Human Genetics and Genome Research Division, National Research Centre, Egypt., Mosaad RM; Molecular Genetics & Enzymology Department , Human Genetics and Genome Research Division, National Research Centre, Egypt., Ramadan A; Molecular Genetics & Enzymology Department , Human Genetics and Genome Research Division, National Research Centre, Egypt.
Jazyk:	angličtina
Zdroj:	Open access Macedonian journal of medical sciences [Open Access Maced J Med Sci] 2017 Oct 17; Vol. 5 (7), pp. 831-835. Date of Electronic Publication: 2017 Oct 17 (Print Publication: 2017).
DOI:	10.3889/oamjms.2017.175
Abstrakt:	Background: Obesity is a multi-factorial chronic disorder. A considerable number of studies have been performed to figure out whether there is an association between obesity and polymorphisms of gene IL-6 (174G/C) , but the results are equivocal. Aim: This study aimed to find out whether the IL-6 (174G/C) gene was associated with the risk of developing obesity in Egyptian children. Subjects and Methods: The study included 149 children and adolescents with age ranged between 9.5 - 18 years. Eighty-five of them were obese which BMIZ-score is > 2, and sixty-four children with BMIZ-score ≤ 2 served as control group. Serum level of IL-6 and genetic analysis for IL-6 (174G/C) gene polymorphism were done. Results: Obese children had significantly higher serum levels of IL-6 as compared to those of control children (P = 0.003). A high percentage of IL-6 polymorphism GC was found in obese subjects (93.7%), while the control group had a higher percentage of IL-6 polymorphism GG (70.6 %). Conclusion: Our study showed that carriers of the C allele for the IL-6 (174G/C) polymorphism have higher BMI. As the G174C polymorphism is likely to affect IL-6 expression and its physiological regulation; consequently this polymorphism may affect adiposity.
Databáze:	MEDLINE
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