Multiple Organ Dysfunction: The Defining Syndrome of Sepsis.

Autor:	Ziesmann MT; Departments of Surgery and Critical Care Medicine, St. Michael's Hospital, University of Toronto , Toronto, Ontario, Canada ., Marshall JC; Departments of Surgery and Critical Care Medicine, St. Michael's Hospital, University of Toronto , Toronto, Ontario, Canada .
Jazyk:	angličtina
Zdroj:	Surgical infections [Surg Infect (Larchmt)] 2018 Feb/Mar; Vol. 19 (2), pp. 184-190. Date of Electronic Publication: 2018 Jan 23.
DOI:	10.1089/sur.2017.298
Abstrakt:	Background: Sepsis as a process has been recognized since the time of the Ancient Greeks. The concept has evolved recently to reflect a disease process of a severe, systemic response to infection. Acute, life-threatening but potentially reversible organ dysfunction is its hallmark, and unresolving organ dysfunction is the dominant cause of death in critical illness. Its evolution, persistence, and resolution reflect a complex interplay of factors originating in the initial inciting insult, the innate immune and metabolic response of the host, and the beneficial and harmful consequences of intensive care unit (ICU) supportive care. Discussion: We describe the common clinical manifestations of the six prototypic organ system dysfunction syndromes of severe sepsis and review the associated epidemiology and suspected pathophysiology.
Databáze:	MEDLINE
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