Serum level of prostate-specific antigen in diabetic patients in Basrah, Iraq.

Autor:	Al-Asadi JN; Department of Community Medicine, College of Medicine, Basrah University, Basrah, Iraq., Al-Naama LM; Department of Biochemistry, College of Medicine, Basrah University, Basrah, Iraq., Abdul-Kareem MM; Department of Biochemistry, College of Medicine, Basrah University, Basrah, Iraq., Mashkoor FC; Department of Biochemistry, College of Pharmacy, Basrah University, Basrah, Iraq.
Jazyk:	angličtina
Zdroj:	The Nigerian postgraduate medical journal [Niger Postgrad Med J] 2017 Oct-Dec; Vol. 24 (4), pp. 240-244.
DOI:	10.4103/npmj.npmj_174_17
Abstrakt:	Objectives: The aim of this study was to determine the effect of type 2 diabetes mellitus (DM) on the serum level of prostate-specific antigen (PSA) in men in Basrah, Iraq. Patients and Methods: A case-control study was done including 70 confirmed type 2 diabetic patients and 70 non-diabetic persons. Data about age and family history of diabetes were collected. For diabetic patients, data related to disease history were also enquired about. Weight and height were measured and body mass index (BMI) was calculated. Blood examination was done to estimate fasting plasma glucose and PSA. Results: The mean ages of diabetic and non-diabetic patients were 55.2 ± 10.5 and 55.9 ± 10.9 years, respectively. The mean total serum PSA was significantly lower among diabetic than non-diabetic men (1.97 ± 1.05 ng/ml vs. 2.60 ± 1.22 ng/ml, respectively, P = 0.001). The multivariate linear regression analysis showed that age, DM and BMI were independent predictors of serum PSA variation. Age was significantly related to PSA in non-diabetics, but not in diabetic patients. Conclusion: Serum PSA level is significantly lower and less age dependent in type 2 diabetic patients than in non-diabetics. Therefore, DM should be considered in setting of PSA threshold when screening for prostate cancer.
Databáze:	MEDLINE
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