Ethyl pyruvate improves skin flap survival after ischaemia reperfusion injury.
| Autor: | Kayiran O; Department Plastic & Reconstructive Surgery, Izmir University, Izmir, Turkey., Cuzdan SS; Plastic Surgery Clinic, Sanmed Private Hospital, Sanliurfa, Turkey., Uysal A; Plastic & Reconstructive Surgery Clinic, TOBB ETU Hospital, Ankara, Turkey., Kocer U; Plastic & Reconstructive Surgery Clinic, Ankara Training & Research Hospital, Ankara, Turkey. |
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| Jazyk: | angličtina |
| Zdroj: | The Indian journal of medical research [Indian J Med Res] 2017 Sep; Vol. 146 (3), pp. 369-374. |
| DOI: | 10.4103/ijmr.IJMR_1428_14 |
| Abstrakt: | Background & Objectives: Reperfusion after ischaemia is detrimental to the tissues. The oxidative stress created and cytokines released are mostly responsible in this process. In this study, ethyl pyruvate, a known agent for its anti-inflammatory and antioxidant properties, was used to investigate the effects on ischaemia/reperfusion injury on skin island flaps in rats. Methods: Sixty rats were randomly distributed in three groups (non-ischaemic, ischaemic and medication groups). Ethyl pyruvate was administered in the medication group with a dose of 50 mg/kg. After 24 h and one week, the animals were sacrificed, and the flaps were analyzed macroscopically, histopathologically, biochemically (total nitrite, malondialdehyde and myeloperoxidase). Results: Biochemical markers indicating oxidative stress, were found elevated in ischaemic group, whereas medication with ethyl pyruvate significantly reduced these values. There was a significant reduction (P<0.05) in the levels of these markers between ischaemic and medication groups. Ethyl pyruvate improved all the parameters significantly. Interpretation & Conclusion: Ethyl pyruvate showed strong scavenger activity against reactive oxygen species. It could be a potential candidate to improve the flap viability in reconstructive microsurgery, especially in free tissue transfers. However, more studies are warranted in experimental models to confirm these findings. |
| Databáze: | MEDLINE |
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