Is dipyrone effective as a preemptive analgesic in third molar surgery? A pilot study.

Autor: Favarini VT; Resident of Oral and Maxillofacial Surgeon, Hospital Geral de Vila Penteado, São Paulo, Brazil., Lima CAA; Resident of Oral and Maxillofacial Surgeon, Hospital Geral de Vila Penteado, São Paulo, Brazil., da Silva RA; Chief of Oral and Maxillofacial Surgery Department, Hospital Geral de Vila Penteado, São Paulo, Brazil., Sato FRL; Department of Oral and Maxillofacial Surgery State University of São Paulo UNESP, College of Dentistry São José dos Campos and Oral and Maxillofacial Surgeon, Hospital Geral de Vila Penteado, Av. Eng. Francisco José Longo, 777, São José dos Campos, SP, 12245-000, Brazil. fabio.sato@ict.unesp.br.
Jazyk: angličtina
Zdroj: Oral and maxillofacial surgery [Oral Maxillofac Surg] 2018 Mar; Vol. 22 (1), pp. 71-75. Date of Electronic Publication: 2018 Jan 20.
DOI: 10.1007/s10006-018-0669-y
Abstrakt: Purpose: Studies on preemptive analgesia in maxillofacial surgery have shown several controversial clinical results, mainly due to the absence of a methodological standard, besides a wide variety of studied drugs. This study intended to answer the following hypothesis: Is the administration of dipyrone preemptively capable of decreasing trans- and postoperative pain in the third molar surgical extraction?
Methods: A pilot prospective double-blind placebo-controlled study was carried out with 25 patients submitted to the third molar surgical extraction at two moments, one side in each intervention. Dipyrone (1 g) was preemptively administered (study group) for the extraction of two third molars on the same side and, in a second surgical procedure, dipyrone (1 g) was administered in the immediate postoperative period (control group). Evaluated variables were the amount of anesthetic, pain perceived through the visual analogue scale (VAS) in transoperative and immediate postoperative periods, and over 12-h investigation period, analgesic consumption, duration of surgery, and time to rescue analgesia.
Results: The results were submitted to Student's t test and statistical differences were observed in transoperative (p < 0.05) and immediate postoperative (p < 0.01) periods, while the other studied variables did not present statistical differences.
Conclusion: The preemptive administration of dipyrone decreased the perception of transoperative and immediate postoperative pain when compared to its use after surgery only.
Databáze: MEDLINE
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