Psychiatric symptoms in preclinical behavioural-variant frontotemporal dementia in MAPT mutation carriers.

Autor:	Cheran G; G H Sergievsky Center & Taub Institute in the Department of Neurology, Columbia University Medical Center, New York, USA., Silverman H; G H Sergievsky Center & Taub Institute in the Department of Neurology, Columbia University Medical Center, New York, USA., Manoochehri M; G H Sergievsky Center & Taub Institute in the Department of Neurology, Columbia University Medical Center, New York, USA., Goldman J; G H Sergievsky Center & Taub Institute in the Department of Neurology, Columbia University Medical Center, New York, USA., Lee S; Department of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York, USA., Wu L; Department of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York, USA., Cines S; G H Sergievsky Center & Taub Institute in the Department of Neurology, Columbia University Medical Center, New York, USA., Fallon E; Department of Neurology, Dublin Neurological Institute at the Mater Misericordiae University Hospital, Dublin, Ireland., Kelly BD; Department of Neurology, Dublin Neurological Institute at the Mater Misericordiae University Hospital, Dublin, Ireland.; Department of Psychiatry, Trinity Centre for Health Sciences, Trinity College Dublin, Tallaght Hospital, Dublin, Ireland., Olszewska DA; Department of Neurology, Dublin Neurological Institute at the Mater Misericordiae University Hospital, Dublin, Ireland., Heidebrink J; Department of Neurology, The University of Michigan, Ann Arbor, Michigan, USA., Shair S; Department of Neurology, The University of Michigan, Ann Arbor, Michigan, USA., Campbell S; Department of Neurology, The University of Michigan, Ann Arbor, Michigan, USA., Paulson H; Department of Neurology, The University of Michigan, Ann Arbor, Michigan, USA., Lynch T; Department of Neurology, Dublin Neurological Institute at the Mater Misericordiae University Hospital, Dublin, Ireland., Cosentino S; G H Sergievsky Center & Taub Institute in the Department of Neurology, Columbia University Medical Center, New York, USA., Huey ED; Departments of Psychiatry & Neurology, Columbia University Medical Center, New York, USA.
Jazyk:	angličtina
Zdroj:	Journal of neurology, neurosurgery, and psychiatry [J Neurol Neurosurg Psychiatry] 2018 May; Vol. 89 (5), pp. 449-455. Date of Electronic Publication: 2018 Jan 20.
DOI:	10.1136/jnnp-2017-317263
Abstrakt:	Objective: To characterise psychiatric symptoms in preclinical and early behavioural-variant frontotemporal dementia (bvFTD), a neurodegenerative disorder whose symptoms overlap with and are often mistaken for psychiatric illness. Methods: The present study reports findings from a systematic, global, prospective evaluation of psychiatric symptoms in 12 preclinical carriers of pathogenic MAPT mutations, not yet meeting bvFTD diagnostic criteria, and 46 familial non-carrier controls. Current psychiatric symptoms, informant-reported symptoms and lifetime prevalence of psychiatric disorders were assessed with The Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) and the Neuropsychiatric Inventory Questionnaire. Fisher exact test was used to compare carriers and non-carriers' lifetime prevalence of six DSM-IV disorders: major depressive disorder, panic attacks, alcohol abuse, generalised anxiety disorder, panic disorder, and depressive disorder not otherwise specified. Other DSM-IV disorders had insufficient prevalence across our sample for between-group comparisons, but are reported. Results: Non-carriers had greater prevalence of mood and anxiety disorders than has been reported for a general reference population. Preclinical carriers had lower lifetime prevalence of mood and anxiety disorders than non-carriers, except for depressive disorder not otherwise specified, an atypical syndrome comprising clinically significant depressive symptoms which fail to meet criteria for major depressive disorder. Conclusion: Findings suggest that early psychiatric symptoms of emergent bvFTD may manifest as emotional blunting or mood changes not cleanly conforming to criteria for a DSM-defined mood disorder. Competing Interests: Competing interests: None declared. (© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.)
Databáze:	MEDLINE
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