The impact of high progesterone levels on the day of HCG administration in assisted human reproduction treatments.

Autor:	Tanada MS; Instituto Ideia Fértil de Saúde Reprodutiva, Santo André - SP, Brazil., Yoshida IH; Instituto Ideia Fértil de Saúde Reprodutiva, Santo André - SP, Brazil.; Faculdade de Medicina do ABC, Santo André - SP, Brazil., Santos M; Instituto Ideia Fértil de Saúde Reprodutiva, Santo André - SP, Brazil.; Faculdade de Medicina do ABC, Santo André - SP, Brazil., Berton CZ; Instituto Ideia Fértil de Saúde Reprodutiva, Santo André - SP, Brazil., Souto E; Instituto Ideia Fértil de Saúde Reprodutiva, Santo André - SP, Brazil., Carvalho WP; Instituto Ideia Fértil de Saúde Reprodutiva, Santo André - SP, Brazil.; Faculdade de Medicina do ABC, Santo André - SP, Brazil., Cordts EB; Instituto Ideia Fértil de Saúde Reprodutiva, Santo André - SP, Brazil.; Faculdade de Medicina do ABC, Santo André - SP, Brazil., Barbosa CP; Instituto Ideia Fértil de Saúde Reprodutiva, Santo André - SP, Brazil.; Faculdade de Medicina do ABC, Santo André - SP, Brazil.
Jazyk:	angličtina
Zdroj:	JBRA assisted reproduction [JBRA Assist Reprod] 2018 Jun 01; Vol. 22 (2), pp. 99-101. Date of Electronic Publication: 2018 Jun 01.
DOI:	10.5935/1518-0557.20180020
Abstrakt:	Objective: Progesterone is a steroid hormone that acts on the endometrium. It is known for producing physical and mood-related side effects. Few studies have looked into how progesterone levels affect embryo development and quality. This study aimed to find a cutoff level for serum progesterone on the day of HCG administration from which embryo quality is impaired. Methods: The study included 145 cycles, from which 885 oocytes and 613 embryos were obtained. All patients had their serum progesterone levels measured on the day of HCG administration. Data sets were collected from patient medical records. The chi-square test was used to assess qualitative variables and the Mann-Whitney test to evaluate quantitative variables. Results: Statistical analysis revealed that serum progesterone levels and reproductive variables were not significantly associated. In regards to oocyte maturity, however, when progesterone levels were greater than 1.3 ng/mL the probability of oocytes being immature increased by 12.7%. The fragmentation rate of embryos categorized as "top quality" in D3 increased proportionately to increases in progesterone levels (12.23%). Conclusion: High progesterone levels appeared to be correlated with increased embryo fragmentation rates, but high serum levels of the hormone on the day of HCG administration had no impact on reproductive variables and were not associated with impaired embryo development.
Databáze:	MEDLINE
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