Two-Photon-Excited Silica and Organosilica Nanoparticles for Spatiotemporal Cancer Treatment.

Autor: Croissant JG; Chemical and Biological Engineering, University of New Mexico, 210 University Blvd NE, Albuquerque, NM, 87131-0001, USA.; Center for Micro-Engineered Materials, Advanced Materials Laboratory, University of New Mexico, MSC04 2790, 1001 University Blvd SE, Suite 103, Albuquerque, NM, 87106, USA., Zink JI; Department of Chemistry and Biochemistry, University of California Los Angeles, 405 Hilgard Avenue, Los Angeles, CA, 90095, USA., Raehm L; Institut Charles Gerhardt de Montpellier, UMR 5253 CNRS-UM-ENSCM, Université de Montpellier, Place Eugène Bataillon, 34095, Montpellier, Cedex 05, France., Durand JO; Institut Charles Gerhardt de Montpellier, UMR 5253 CNRS-UM-ENSCM, Université de Montpellier, Place Eugène Bataillon, 34095, Montpellier, Cedex 05, France.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2018 Apr; Vol. 7 (7), pp. e1701248. Date of Electronic Publication: 2018 Jan 18.
DOI: 10.1002/adhm.201701248
Abstrakt: Coherent two-photon-excited (TPE) therapy in the near-infrared (NIR) provides safer cancer treatments than current therapies lacking spatial and temporal selectivities because it is characterized by a 3D spatial resolution of 1 µm 3 and very low scattering. In this review, the principle of TPE and its significance in combination with organosilica nanoparticles (NPs) are introduced and then studies involving the design of pioneering TPE-NIR organosilica nanomaterials are discussed for bioimaging, drug delivery, and photodynamic therapy. Organosilica nanoparticles and their rich and well-established chemistry, tunable composition, porosity, size, and morphology provide ideal platforms for minimal side-effect therapies via TPE-NIR. Mesoporous silica and organosilica nanoparticles endowed with high surface areas can be functionalized to carry hydrophobic and biologically unstable two-photon absorbers for drug delivery and diagnosis. Currently, most light-actuated clinical therapeutic applications with NPs involve photodynamic therapy by singlet oxygen generation, but low photosensitizing efficiencies, tumor resistance, and lack of spatial resolution limit their applicability. On the contrary, higher photosensitizing yields, versatile therapies, and a unique spatial resolution are available with engineered two-photon-sensitive organosilica particles that selectively impact tumors while healthy tissues remain untouched. Patients suffering pathologies such as retinoblastoma, breast, and skin cancers will greatly benefit from TPE-NIR ultrasensitive diagnosis and therapy.
(© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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