O-GlcNAcylation: key regulator of glycolytic pathways.

Autor: Bacigalupa ZA; Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, 245 N. 15th Street, Philadelphia, PA, 19102, USA., Bhadiadra CH; Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, 245 N. 15th Street, Philadelphia, PA, 19102, USA., Reginato MJ; Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, 245 N. 15th Street, Philadelphia, PA, 19102, USA. Mauricio.Reginato@drexelmed.edu.
Jazyk: angličtina
Zdroj: Journal of bioenergetics and biomembranes [J Bioenerg Biomembr] 2018 Jun; Vol. 50 (3), pp. 189-198. Date of Electronic Publication: 2018 Jan 18.
DOI: 10.1007/s10863-018-9742-3
Abstrakt: Elevated O-GlcNAcylation is emerging as a general characteristic of most cancers. Although O-GlcNAcylation can regulate many cell biological pathways, recent evidence suggests that it is a key regulator of metabolic pathways including glycolysis in cancer cells. This review summarizes our current understanding of how O-GlcNAcylation regulates glycolytic pathways and contributes to alterations in cancer cell metabolism.
Databáze: MEDLINE
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