| Autor: |
Cullinane C; Peter MacCallum Cancer Center, 305 Grattan Street, Melbourne Vic 3000, Australia and Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Melbourne Vic 3052, Australia., Deacon GB, Drago PR, Erven AP, Junk PC, Luu J, Meyer G, Schmitz S, Ott I, Schur J, Webster LK, Klein A |
| Abstrakt: |
New organometallic complexes [M(dppe)(R) 2 ] {where M = Pt or Pd, dppe = 1,2-bis(diphenylphosphano)ethane, and R = C 6 F 4 H-x (x = 6,5,4), C 6 F 3 H 2 -3,5, C 6 F 3 H 2 -5,6, C 6 F 3 H 2 -3,6, C 6 F 4 (OMe)-4, and C 6 F 4 (cyclo-C 5 H 10 N)-4, the numbers x refer to the positions of the protons in the polyfluoroaryl ligands} were synthesised either through transmetalation from the dichlorido complexes [M(dppe)Cl 2 ] or through ligand exchange using [M(diene)Cl 2 ] precursor complexes with diene = 1,5-cyclooctadiene (cod) or 1,5-hexadiene (hex). Alternatively, [M(dppX)Cl(R)] complexes with dppX = dppm (1,1-bis(diphenylphosphano)methane), dppe, dppp (1,3-bis(diphenylphosphano)propane), and dppb (1,4-bis(diphenylphosphano)butane) were prepared in decarboxylation reactions from thallium(i) carboxylates Tl(O 2 CR). The different preparative methods were compared in terms of yield and purity. Structural and spectroscopic data are reported for the new dppX- and diene-M(R) 2 complexes. Antiproliferative activity was investigated for these new complexes against the HT-29 (colon carcinoma) and MCF-7 (breast adenocarcinoma) cell lines, and the active compounds of this first series together with organometallic dppX or hex Pt II or Pd II complexes were then included in cell tests using L1210 (leukaemia cells) and the cisplatin-resistant L1210/DDP cell line. Remarkably, promising antiproliferative results were found for a few Pt II and Pd II complexes, while structurally closely related compounds were essentially nontoxic. |
