Life Expectancy for Patients From the Southeastern United States With IgA Nephropathy.

Autor:	Hastings MC; Department of Pediatrics, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA.; Department of Medicine, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA.; Children's Foundation Research Institute, Memphis, Tennessee, USA., Bursac Z; Department of Preventive Medicine, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA.; Center for Population Sciences, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA., Julian BA; Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA., Villa Baca E; Center for Biomedical Informatics, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA., Featherston J; Center for Biomedical Informatics, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA., Woodford SY; Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA., Bailey L; Department of Pediatrics, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA., Wyatt RJ; Department of Pediatrics, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA.; Children's Foundation Research Institute, Memphis, Tennessee, USA.
Jazyk:	angličtina
Zdroj:	Kidney international reports [Kidney Int Rep] 2017 Aug 24; Vol. 3 (1), pp. 99-104. Date of Electronic Publication: 2017 Aug 24 (Print Publication: 2018).
DOI:	10.1016/j.ekir.2017.08.008
Abstrakt:	Introduction: Although end-stage renal disease (ESRD) and surrogate markers for renal dysfunction are frequently used as outcome markers for IgA nephropathy, the clinical course after reaching ESRD is not well documented. This study examined outcomes of progression to ESRD and age at death in a cohort of adults with IgA nephropathy with a long duration of follow-up. Methods: Patient and kidney survival of 251 adult patients with IgA nephropathy from the southeastern United States diagnosed between January 1, 1976 and December 31, 2005 were analyzed. Results: Median age at diagnosis was 36.9 years. Most patients were men (69%) and Caucasian (95%). Only 46% had an estimated glomerular filtration rate >60 ml/min per 1.73 m 2 at diagnosis. Mean follow-up time from time of diagnostic biopsy to death or end of study was 19.3 years. Of 251 patients, 132 (53%) progressed to ESRD and 97 (39%) died. Life expectancy was reduced by 10.1 years, with a median observed age of death at 65.7 years and a median expected age at death of 75.8 years. Eighty-three percent of the deaths occurred after progression to ESRD. Conclusion: Life expectancy is substantially reduced for patients diagnosed with IgA nephropathy in the southeastern United States.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu