Surface-based characteristics of the cerebellar cortex visualized with ultra-high field MRI.

Autor: Boillat Y; Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Electronic address: yohan.boillat@epfl.ch., Bazin PL; Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany., O'Brien K; Siemens Healthcare Pty Ltd., Bowen Hills, Australia; Centre for Advanced Imaging, University of Queensland, Australia., Fartaria MJ; Department of Radiology, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland; Advanced Clinical Imaging Technology (ACIT, HC CEMEA SUI DI BM PI), Siemens Healthcare AG, Lausanne, Switzerland., Bonnier G; A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA., Krueger G; Siemens Medical Solutions USA IM MR COL NEZ, Burlington, MA, USA., van der Zwaag W; Biomedical Imaging Research Center, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; Spinoza Centre for Neuroimaging, Amsterdam, Switzerland., Granziera C; A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA; Neurology, Department of Clinical Neurosciences, CHUV and University of Lausanne, Netherlands.
Jazyk: angličtina
Zdroj: NeuroImage [Neuroimage] 2018 May 15; Vol. 172, pp. 1-8. Date of Electronic Publication: 2018 Jan 13.
DOI: 10.1016/j.neuroimage.2018.01.016
Abstrakt: Although having a relatively homogeneous cytoarchitectonic organization, the cerebellar cortex is a heterogeneous region characterized by different amounts of myelin, iron and protein expression profiles. In this study, we used quantitative T 1 and T 2 * mapping at ultra-high field (7T) MRI to investigate the tissue characteristics of the cerebellar gray matter surface and its layers. Detailed subject-specific surfaces were generated at three different cortical depths and averaged across subjects to create averaged T 1 - and T 2 *-maps on the cerebellar surface. T 1 surfaces showed an alternation of lower and higher T 1 values when going from the median to the lateral part of the cerebellar hemispheres. In addition, longer T 1 values were observed in the more superficial gray matter layers. T 2 *-maps showed a similar longitudinal pattern, but no change related to the cortical depths. These patterns are possibly due to variations in the level of myelination, iron and zebrin protein expression.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: