Absence of toxicity in Swiss mice following treatment with 7-acetoxy-4-aryl-3,4-dihydrocoumarin: Acute and repeated-dose toxicity study.

Autor: Saldanha GB; Institute of Chemistry, Federal University of Bahia, Salvador, Bahia, 40170-280, Brazil., Saldanha GB; Institute of Chemistry, Federal University of Bahia, Salvador, Bahia, 40170-280, Brazil., de Sousa MRSC; Department of Veterinary Morphophysiology, Federal University of Piaui, School of Agrarians Sciences, Teresina, Piauí, 64049-550, Brazil., Oliveira GLDS; Department of Pharmacy, Federal University of Piauí, Teresina, Piauí, 64049-550, Brazil; Department of Biology, Center for Higher Studies of Coelho Neto, State University of Maranhão, Coelho Neto, Maranhão, 65.620-000, Brazil. Electronic address: georggeoliveira@outlook.com., da Silva APDSCL; Department of Pharmacy, Federal University of Piauí, Teresina, Piauí, 64049-550, Brazil., David JM; Institute of Chemistry, Federal University of Bahia, Salvador, Bahia, 40170-280, Brazil., David JP; Institute of Chemistry, Federal University of Bahia, Salvador, Bahia, 40170-280, Brazil.
Jazyk: angličtina
Zdroj: Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2018 Apr; Vol. 94, pp. 75-82. Date of Electronic Publication: 2018 Jan 13.
DOI: 10.1016/j.yrtph.2018.01.003
Abstrakt: Neoflavonoids, which are classified as 4-arylcoumarin (neoflavone), 3,4-dihydro-4-arylcoumarin and neoflavene, have been the subject of a number of studies with respect to their therapeutic potential and, despite promising in vitro, ex vivo and in vivo pharmacological activities, there is a lack of studies demonstrating their toxicological properties. Therefore, this study aims to evaluate the acute (14 days) and repeated-dose (28 days) toxicity of synthetic neoflavonoid 7-acetoxy-4-aryl-3,4-dihydrocoumarin in Swiss mice through parameters related to changes in body weight, food and water intake, hematological and biochemical parameters. Toxicity studies using acute doses (300 and 2000 mg/kg) and repeated doses (250, 500 and 1000 mg/kg) orally were carried out as per Organization for Economic Co-operation and Development (OECD) guidelines 423 and 407, respectively. Based on the results of this study, treatment with 7-acetoxy-4-aryl-3,4-dihydrocoumarin was found to not cause clinical adverse symptoms and mortality in any animal used in the acute and repeated-dose toxicity study. In addition, no significant changes were observed in body weight and internal organs, food and water intake, hematological and biochemical parameters, compared to control group. Therefore, these results provide an initial understanding regarding the toxicity profile of 7-acetoxy-4-aryl-3,4-dihydrocoumarin, which can be considered a neoflavonoid with toxicity seen at doses higher than 2000 mg/kg in Swiss mice.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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