| Autor: |
Pajić NZB; 1Department of Pharmaceutical Technology and Cosmetology Faculty of Medicine, University of Banja Luka, 78000 Banja Luka Bosnia and Herzegovina., Todosijević MN; 2Department of Pharmaceutical Technology and Cosmetology Faculty of Pharmacy, University of Belgrade, 11221 Belgrade, Serbia., Vuleta GM; 2Department of Pharmaceutical Technology and Cosmetology Faculty of Pharmacy, University of Belgrade, 11221 Belgrade, Serbia., Cekić ND; 3Faculty of Technology, University of Niš, 16000 Leskovac, Serbia., Dobričić VD; 5Department of Pharmaceutical Chemistry, Faculty of Pharmacy University of Belgrade, Belgrade, Serbia., Vučen SR; 6School of Pharmacy, University College Cork, Cork, Ireland., Čalija BR; 2Department of Pharmaceutical Technology and Cosmetology Faculty of Pharmacy, University of Belgrade, 11221 Belgrade, Serbia., Lukić MŽ; 2Department of Pharmaceutical Technology and Cosmetology Faculty of Pharmacy, University of Belgrade, 11221 Belgrade, Serbia., Ilić TM; 2Department of Pharmaceutical Technology and Cosmetology Faculty of Pharmacy, University of Belgrade, 11221 Belgrade, Serbia., Savić SD; 2Department of Pharmaceutical Technology and Cosmetology Faculty of Pharmacy, University of Belgrade, 11221 Belgrade, Serbia. |
| Abstrakt: |
Two types of biocompatible surfactants were evaluated for their capability to formulate skin-friendly/non-irritant microemulsions as vehicles for two poorly water-soluble model drugs differing in properties and concentrations: alkyl polyglucosides (decyl glucoside and caprylyl/capryl glucoside) and ethoxylated surfactants (glycereth-7-caprylate/ caprate and polysorbate 80). Phase behavior, structural inversion and microemulsion solubilization potential for sertaconazole nitrate and adapalene were found to be highly dependent on the surfactants structure and HLB value. Performed characterization (polarized light microscopy, pH, electrical conductivity, rheological, FTIR and DSC measurements) indicated a formulation containing glycereth- 7-caprylate/caprate as suitable for incorporation of both drugs, whereas alkyl polyglucoside-based systems did not exhibit satisfying solubilization capacity for sertaconazole nitrate. Further, monitored parameters were strongly affected by sertaconazole nitrate incorporation, while they remained almost unchanged in adapalene-loaded vehicles. In addition, results of the in vivo skin performance study supported acceptable tolerability for all investigated formulations, suggesting selected microemulsions as promising carriers worth exploring further for effective skin delivery of model drugs. |
