Acrodermatitis acidaemica.

Autor: Maguire CA; Department of Dermatology, St George's Healthcare NHS Trust, London, UK., Chong H; Department of Cellular Pathology, St George's Healthcare NHS Trust, London, UK., Ramachandran R; Department of Chemical Pathology and Metabolic Medicine, Guy's and St Thomas' NHS Foundation Trust, London, UK., Popoola J; Department of Nephrology, St George's Healthcare NHS Trust, London, UK., Akhras V; Department of Dermatology, St George's Healthcare NHS Trust, London, UK., Singh M; Department of Dermatology, St George's Healthcare NHS Trust, London, UK.
Jazyk: angličtina
Zdroj: Clinical and experimental dermatology [Clin Exp Dermatol] 2018 Apr; Vol. 43 (3), pp. 315-318. Date of Electronic Publication: 2018 Jan 15.
DOI: 10.1111/ced.13369
Abstrakt: Methylmalonic acidaemia (MMA) is an inborn error of amino acid metabolism that may be associated with cutaneous manifestations mimicking other diagnoses, including staphylococcal scalded skin syndrome (SSSS), psoriasis and acrodermatitis enteropathica. Whether this is due to the underlying metabolic disorder itself or occurs as a consequence of dietary restriction has yet to be elucidated. Skin biopsies typically show histological features shared by a number of other metabolic disorders and nutritional deficiency-associated diseases. Some presentations, especially SSSS-like eruptions, may be associated with acute metabolic decompensation. An underlying metabolic disorder, such as MMA, should be considered in a diagnosed adult or undiagnosed child presenting with skin eruptions that resemble those listed above, so that specialist management may be initiated early.
(© 2018 British Association of Dermatologists.)
Databáze: MEDLINE
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