Clinical Outcomes of First-line Abiraterone Acetate or Enzalutamide for Metastatic Castration-resistant Prostate Cancer After Androgen Deprivation Therapy + Docetaxel or ADT Alone for Metastatic Hormone-sensitive Prostate Cancer.

Autor: Francini E; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; Sapienza Università di Roma, Rome, Italy., Yip S; Tom Baker Cancer Centre, Calgary, AB, Canada., Ahmed S; Tom Baker Cancer Centre, Calgary, AB, Canada., Li H; Departments of Oncology and Community Health Sciences, University of Calgary, Calgary, AB, Canada., Ardolino L; St Vincent's Hospital, Sydney, Australia., Evan CP; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA., Kaymakcalan M; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA., Shaw GK; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA., Kantoff PW; Memorial Sloan Kettering Cancer Center, New York, NY., Taplin ME; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA., Alimohamed NS; Tom Baker Cancer Centre, Calgary, AB, Canada., Joshua AM; St Vincent's Hospital, Sydney, Australia., Heng DYC; Tom Baker Cancer Centre, Calgary, AB, Canada., Sweeney CJ; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA. Electronic address: christopher_sweeney@dfci.harvard.edu.
Jazyk: angličtina
Zdroj: Clinical genitourinary cancer [Clin Genitourin Cancer] 2018 Apr; Vol. 16 (2), pp. 130-134. Date of Electronic Publication: 2017 Dec 27.
DOI: 10.1016/j.clgc.2017.12.012
Abstrakt: Background: The CHAARTED (ChemoHormonal Therapy Versus Androgen Ablation Randomized Trial for Extensive Disease in Prostate Cancer) and STAMPEDE (Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy) trials showed that the addition of docetaxel (D) to androgen deprivation therapy (ADT) prolonged longevity of men with metastatic hormone-sensitive prostate cancer (mHSPC). However, the impact of upfront D on subsequent therapies is still unexplored. As abiraterone acetate (AA) and enzalutamide (E) are the most commonly used first-line treatment for metastatic castration-resistant prostate cancer (mCRPC), we aimed to assess whether they maintained their efficacy after ADT+D versus ADT alone.
Patients and Methods: A cohort of patients with mCRPC treated between 2014 and 2017 with first-line AA or E for mCRPC was identified from 3 hospitals' institutional review board-approved databases. Patients were classified by use of D for mHSPC. This time frame was chosen as ADT+D became a valid therapeutic option for mHSPC in 2014, and it inherently entailed a short follow-up time on AA/E. The endpoints included overall survival from ADT start, overall survival from AA/E start, and time to AA/E start from ADT start. Differences between groups were assessed using the log-rank test.
Results: Of the 102 patients with mCRPC identified, 50 (49%) had previously received ADT alone, while 52 (51%) had ADT+D. No statistically significant difference in any of the evaluated outcomes was observed between the 2 cohorts. Yet, deaths in the ADT+D group were 12 versus 21 in the ADT alone, after a median follow-up of 24.4 and 29.8 months, respectively.
Conclusion: In a cohort of ADT/ADT+D-treated patients with mCRPC with short times to first-line AA/E and follow-up, the efficacy of AA/E is similar regardless of previous use of D.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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