Deracemization of a Racemic Compound by Using Tailor-Made Additives.

Autor: Engwerda AHJ; Radboud University Nijmegen, Nijmegen, The Netherlands., van Schayik P; Radboud University Nijmegen, Nijmegen, The Netherlands., Jagtenberg H; Radboud University Nijmegen, Nijmegen, The Netherlands., Meekes H; Radboud University Nijmegen, Nijmegen, The Netherlands., Rutjes FPJT; Radboud University Nijmegen, Nijmegen, The Netherlands., Vlieg E; Radboud University Nijmegen, Nijmegen, The Netherlands.
Jazyk: angličtina
Zdroj: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2018 Feb 26; Vol. 24 (12), pp. 2863-2867. Date of Electronic Publication: 2018 Feb 01.
DOI: 10.1002/chem.201706088
Abstrakt: Viedma ripening is a process that combines abrasive grinding of a slurry of crystals with solution-phase racemization, resulting in solid-phase deracemization. One of the major disadvantages of Viedma ripening is that the desired compound needs to crystallize as a racemic conglomerate, accounting for only 5-10 % of all chiral molecules. Herein, we show that use of a chiral additive causes deracemization under conditions, in which the compound normally crystallizes as a racemic compound. Although this concerns a single example, it is envisioned that through this new approach the scope of Viedma ripening can be significantly expanded.
(© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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