| Autor: |
Srinivasulu V, Sieburth SM; Department of Chemistry, Temple University , 201 Beury Hall, Philadelphia, Pennsylvania 19122, United States., El-Awady R, Kariem NM, Tarazi H, O'Connor MJ; New York University Abu Dhabi , P.O. Box 129188, Saadiyat Island, Abu Dhabi, UAE., Al-Tel TH |
| Jazyk: |
angličtina |
| Zdroj: |
Organic letters [Org Lett] 2018 Feb 02; Vol. 20 (3), pp. 836-839. Date of Electronic Publication: 2018 Jan 12. |
| DOI: |
10.1021/acs.orglett.7b03986 |
| Abstrakt: |
Employing a build/couple/pair strategy, a serendipitous one-pot protocol for the diastereoselective construction of diverse collections of chromenopyrroles is described. This methodology features an unprecedented five-step cascade including azomethine ylide generation followed by in situ intramolecular [3 + 2]-cycloaddition. Furthermore, this protocol was extended to access enantiopure chromenopyrroles using amino acids as chiral auxiliary. Moreover, postpairing reactions were employed to increase the diversity and complexity of our pilot compound collections. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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