Comparative analysis of the safety and efficacy of intracameral cefuroxime, moxifloxacin and vancomycin at the end of cataract surgery: a meta-analysis.

Autor:	Bowen RC; Department of Ophthalmology, University of Wisconsin, Madison, Wisconsin, USA., Zhou AX; Department of Ophthalmology, University of Utah, Salt Lake City, Utah, USA., Bondalapati S; Department of Ophthalmology, University of Utah, Salt Lake City, Utah, USA., Lawyer TW; Department of Ophthalmology, University of Utah, Salt Lake City, Utah, USA., Snow KB; Department of Pharmacy, University of Utah, Salt Lake City, Utah, USA., Evans PR; Department of Ophthalmology, University of Utah, Salt Lake City, Utah, USA., Bardsley T; Department of Ophthalmology, University of Utah, Salt Lake City, Utah, USA., McFarland M; Department of Ophthalmology, University of Utah, Salt Lake City, Utah, USA., Kliethermes M; Department of Ophthalmology, University of Utah, Salt Lake City, Utah, USA., Shi D; Department of Ophthalmology, University of Utah, Salt Lake City, Utah, USA., Mamalis CA; Department of Ophthalmology, University of Utah, Salt Lake City, Utah, USA., Greene T; Department of Ophthalmology, University of Utah, Salt Lake City, Utah, USA., Rudnisky CJ; Department of Ophthalmology, University of Alberta, Edmonton, Alberta, Canada., Ambati BK; Department of Ophthalmology, University of Utah, Salt Lake City, Utah, USA.
Jazyk:	angličtina
Zdroj:	The British journal of ophthalmology [Br J Ophthalmol] 2018 Sep; Vol. 102 (9), pp. 1268-1276. Date of Electronic Publication: 2018 Jan 11.
DOI:	10.1136/bjophthalmol-2017-311051
Abstrakt:	Background: Current practice methods are unclear as to the most safe and effective prophylactic pharmacotherapy and method of delivery to reduce postoperative endophthalmitis occurrence. Methods: A systematic review and meta-analysis using Meta-analysis of Observational Studies in Epidemiology guidelines was performed to compare the efficacy of intracameral cefuroxime, moxifloxacin and vancomycin in preventing postphacoemulsification cataract surgery endophthalmitis. A safety analysis of intracameral antibiotics was concurrently performed. Data Sources: BIOSIS Previews, CINAHL, ClinicalTrials.gov, Cochrane Library, Dissertations & Theses, EMBASE, PubMed, ScienceDirect and Scopus were searched from inception to January 2017. Data were pooled using a random effects model. All articles were individually reviewed and data were extracted by two independent reviewers. Funnel plot, risk of bias and quality of evidence analyses were performed. Results: Seventeen studies with over 900 000 eyes were included, which favoured the use of intracameral antibiotics at the end of cataract surgery (OR 0.20; 95% CI 0.13 to 0.32; P<0.00001). The average weighted postoperative endophthalmitis incidence rates with intracameral cefuroxime, moxifloxacin and vancomycin were 0.0332%, 0.0153% and 0.0106%, respectively. Secondary analyses showed no difference in efficacy between intracameral plus topical antibiotics versus intracameral alone (P>0.3). Most studies had low to moderate risk of bias. The safety analysis showed minimal toxicity for moxifloxacin. Dosing errors led to the majority of toxicities with cefuroxime. Although rare, vancomycin was associated with toxic retinal events. Conclusion: Intracameral cefuroxime and moxifloxacin reduced endophthalmitis rates compared with controls with minimal or no toxicity events at standard doses. Additionally, intracameral antibiotics alone may be as effective as intracameral plus topical antibiotics. Competing Interests: Competing interests: None declared. (© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.)
Databáze:	MEDLINE
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