Serum podocalyxin levels correlate with carotid intima media thickness, implicating its role as a novel biomarker for atherosclerosis.

Autor:	Shoji M; Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba, 260-8670, Japan.; Department of Medicine, Division of Diabetes, Metabolism and Endocrinology, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba, 260-8670, Japan., Takemoto M; Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba, 260-8670, Japan. minoru.takemoto@iuhw.ac.jp.; School of Medicine, International University of Health and Welfare, Department of Diabetes, Metabolism and Endocrinology, 4-3 Kozunomori, Narita-shi, Chiba, 286-8686, Japan. minoru.takemoto@iuhw.ac.jp., Kobayashi K; Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba, 260-8670, Japan.; Asahi Chuo Hospital, 1326, Ino, Asahi-shi, Chiba, 289-2511, Japan., Shoji T; Department of Cardiology, Chiba Emergency Medical Center, Chiba, 3-32-1, Isobe, Mihama-ku, Chiba-shi, Chiba, 261-0012, Japan., Mori S; Life Inovation Research Institute, Denka Co., Ltd, 3-5-1, Asahi-Machi, Machida-City, Tokyo, 194-0023, Japan., Sagara JI; Life Inovation Research Institute, Denka Co., Ltd, 3-5-1, Asahi-Machi, Machida-City, Tokyo, 194-0023, Japan., Kurosawa H; R&D Center, Denka Seikne Co., Ltd, 1359-1, Kagamida, Kigoshi, Gosen-City, Niigata, 959-1695, Japan., Hirayama Y; R&D Center, Denka Seikne Co., Ltd, 1359-1, Kagamida, Kigoshi, Gosen-City, Niigata, 959-1695, Japan., Sakamoto K; Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba, 260-8670, Japan.; Department of Medicine, Division of Diabetes, Metabolism and Endocrinology, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba, 260-8670, Japan., Ishikawa T; Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba, 260-8670, Japan.; Department of Medicine, Division of Diabetes, Metabolism and Endocrinology, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba, 260-8670, Japan., Koshizaka M; Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba, 260-8670, Japan.; Department of Medicine, Division of Diabetes, Metabolism and Endocrinology, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba, 260-8670, Japan., Maezawa Y; Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba, 260-8670, Japan.; Department of Medicine, Division of Diabetes, Metabolism and Endocrinology, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba, 260-8670, Japan., Yokote K; Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba, 260-8670, Japan.; Department of Medicine, Division of Diabetes, Metabolism and Endocrinology, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba, 260-8670, Japan.
Jazyk:	angličtina
Zdroj:	Scientific reports [Sci Rep] 2018 Jan 10; Vol. 8 (1), pp. 245. Date of Electronic Publication: 2018 Jan 10.
DOI:	10.1038/s41598-017-18647-6
Abstrakt:	Podocalyxin is a cell surface sialomucin, which is expressed in not only glomerular podocytes but also vascular endothelial cells. Urinary podocalyxin is used as a marker for glomerular disease. However, there are no reports describing serum podocalyxin (s-Podxl) levels. Therefore, the association between s-Podxl levels and clinical parameters were examined with 52 patients. s-Podxl level was evaluated using enzyme-linked immunosorbent assay. The median s-Podxl level was 14.2 ng/dL (interquartile range: 10.8-22.2 ng/dL). There were significant correlations (correlation coefficient: r > 0.2) of s-Podxl levels with carotid intima media thickness (IMT) (r = 0.30, p = 0.0307). Multiple logistic regression analysis showed that s-Podxl levels remained significantly associated with carotid IMT > 1 mm (OR: 1.15; 95% CI 1.02-1.31, p = 0.026) after adjustments for traditional cardiovascular risk factors such as age, sex, current smoking status, hypertension, dyslipidemias, and diabetes. In conclusion, s-Podxl is independently associated with carotid IMT and might be used as a novel biomarker for cardiovascular disease.
Databáze:	MEDLINE
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