Mitochondrial network complexity emerges from fission/fusion dynamics.

Autor: Zamponi N; Mitochondrial Research Group, Instituto de Investigaciones Médicas Mercedes y Martín Ferreyra y Universidad Nacional de Córdoba (INIMEC-CONICET-UNC), Friuli 2434, (5016), Córdoba, Argentina. zamponi.n@gmail.com.; Department of Medicine, Hematology and Oncology Division, Weill Cornell Medicine, New York, New York, 10065, USA. zamponi.n@gmail.com., Zamponi E; Mitochondrial Research Group, Instituto de Investigaciones Médicas Mercedes y Martín Ferreyra y Universidad Nacional de Córdoba (INIMEC-CONICET-UNC), Friuli 2434, (5016), Córdoba, Argentina., Cannas SA; Facultad de Matemática, Astronomía, Física y Computación, Universidad Nacional de Córdoba, Instituto de Física Enrique Gaviola (IFEG-CONICET), Ciudad Universitaria, (5000), Córdoba, Argentina.; Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Godoy Cruz 2290, (1425), Buenos Aires, Argentina., Billoni OV; Facultad de Matemática, Astronomía, Física y Computación, Universidad Nacional de Córdoba, Instituto de Física Enrique Gaviola (IFEG-CONICET), Ciudad Universitaria, (5000), Córdoba, Argentina.; Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Godoy Cruz 2290, (1425), Buenos Aires, Argentina., Helguera PR; Mitochondrial Research Group, Instituto de Investigaciones Médicas Mercedes y Martín Ferreyra y Universidad Nacional de Córdoba (INIMEC-CONICET-UNC), Friuli 2434, (5016), Córdoba, Argentina. phelguera@immf.uncor.edu.; Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Godoy Cruz 2290, (1425), Buenos Aires, Argentina. phelguera@immf.uncor.edu., Chialvo DR; Center for Complex Systems and Brain Sciences (CEMSC3), Universidad Nacional de San Martín, Campus Miguelete, 25 de Mayo y Francia, (1650), San Martín, Buenos Aires, Argentina.; Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Godoy Cruz 2290, (1425), Buenos Aires, Argentina.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2018 Jan 10; Vol. 8 (1), pp. 363. Date of Electronic Publication: 2018 Jan 10.
DOI: 10.1038/s41598-017-18351-5
Abstrakt: Mitochondrial networks exhibit a variety of complex behaviors, including coordinated cell-wide oscillations of energy states as well as a phase transition (depolarization) in response to oxidative stress. Since functional and structural properties are often interwinded, here we characterized the structure of mitochondrial networks in mouse embryonic fibroblasts using network tools and percolation theory. Subsequently we perturbed the system either by promoting the fusion of mitochondrial segments or by inducing mitochondrial fission. Quantitative analysis of mitochondrial clusters revealed that structural parameters of healthy mitochondria laid in between the extremes of highly fragmented and completely fusioned networks. We confirmed our results by contrasting our empirical findings with the predictions of a recently described computational model of mitochondrial network emergence based on fission-fusion kinetics. Altogether these results offer not only an objective methodology to parametrize the complexity of this organelle but also support the idea that mitochondrial networks behave as critical systems and undergo structural phase transitions.
Databáze: MEDLINE
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