Therapeutic role of rifampicin in Alzheimer's disease.

Autor: Yulug B; Department of Neurology, Istanbul Medipol University, Istanbul, Turkey.; Department of Restorative and Regenerative Medicine, Istanbul Medipol University, Istanbul, Turkey., Hanoglu L; Department of Neurology, Istanbul Medipol University, Istanbul, Turkey.; Department of Restorative and Regenerative Medicine, Istanbul Medipol University, Istanbul, Turkey., Ozansoy M; Department of Restorative and Regenerative Medicine, Istanbul Medipol University, Istanbul, Turkey.; Department of Physiology, International School of Medicine, Istanbul Medipol University, Istanbul, Turkey., Isık D; Department of Psychiatry, Istanbul Medipol University, Istanbul, Turkey., Kilic U; Department of Medical Biology, Faculty of Medicine, University of Health Sciences, Istanbul, Turkey., Kilic E; Department of Restorative and Regenerative Medicine, Istanbul Medipol University, Istanbul, Turkey.; Department of Physiology, International School of Medicine, Istanbul Medipol University, Istanbul, Turkey., Schabitz WR; Department of Neurology, Bethel, EVKB, Bielefeld, University of Münster, Münster, Germany.
Jazyk: angličtina
Zdroj: Psychiatry and clinical neurosciences [Psychiatry Clin Neurosci] 2018 Mar; Vol. 72 (3), pp. 152-159. Date of Electronic Publication: 2018 Feb 10.
DOI: 10.1111/pcn.12637
Abstrakt: Rifampicin exerts significant brain protective functions in multiple experimental models. Here we summarize the underlying mechanisms of the neuroprotective and pro-cognitive effects of rifampicin that are mediated by its anti-inflammatory, anti-tau, anti-amyloid, and cholinergic effects. Beyond suggesting that rifampicin shows strong brain protective effects in preclinical models of Alzheimer's disease, we also provide substantial clinical evidence for the neuroprotective and pro-cognitive effects of rifampicin. Future neuroimaging studies combined with clinical assessment scores are the following steps to be taken in this field of research.
(© 2018 The Authors. Psychiatry and Clinical Neurosciences © 2018 Japanese Society of Psychiatry and Neurology.)
Databáze: MEDLINE
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