Toenail mercury Levels are associated with amyotrophic lateral sclerosis risk.

Autor: Andrew AS; Department of Neurology, Geisel School of Medicine at Dartmouth, 7936 Rubin Building, One Medical Center Drive, Lebanon, NH, 03756, USA., Chen CY; Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire, USA.; Department of Earth Sciences, Dartmouth College, Hanover, New Hampshire, USA., Caller TA; Cheyenne Regional Medical Center, Medical Specialty Clinic, Cheyenne, Wyoming, USA., Tandan R; Department of Neurological Sciences, University of Vermont Medical Center, Burlington, Vermont, USA., Henegan PL; Department of Neurology, Geisel School of Medicine at Dartmouth, 7936 Rubin Building, One Medical Center Drive, Lebanon, NH, 03756, USA., Jackson BP; Department of Earth Sciences, Dartmouth College, Hanover, New Hampshire, USA., Hall BP; Department of Neurology, Geisel School of Medicine at Dartmouth, 7936 Rubin Building, One Medical Center Drive, Lebanon, NH, 03756, USA., Bradley WG; Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida, USA., Stommel EW; Department of Neurology, Geisel School of Medicine at Dartmouth, 7936 Rubin Building, One Medical Center Drive, Lebanon, NH, 03756, USA.
Jazyk: angličtina
Zdroj: Muscle & nerve [Muscle Nerve] 2018 Jan 04. Date of Electronic Publication: 2018 Jan 04.
DOI: 10.1002/mus.26055
Abstrakt: Introduction: Mercury is a neurotoxic metal that is potentially a risk factor for amyotrophic lateral sclerosis (ALS). Consumption of methylmercury contaminated fish is the primary source of US population exposure to mercury.
Methods: We used inductively coupled plasma mass spectrometry to measure levels of mercury in toenail samples from patients with ALS (n = 46) and from controls (n = 66) as a biomarker of mercury exposure.
Results: Patients with ALS had higher toenail mercury levels (odds ratio 2.49, 95% confidence interval 1.18-5.80, P = 0.024) compared with controls, adjusted for age and sex. We also estimated the amount of mercury consumed from finfish and shellfish and found toenail mercury levels elevated overall among patients with ALS and controls in the top quartile for consumption (P = 0.018).
Discussion: Biomarker data show that ALS is associated with increased with mercury levels, which were related to estimated methylmercury intake via fish. Replication of these associations in additional populations is warranted. Muscle Nerve, 2018.
(© 2018 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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