Specific Features of Immediate Ultrastructural Changes in Brain Cortex Mitochondria of Rats with Different Tolerance to Hypoxia under Various Modes of Hypoxic Exposures.

Autor: Pavlik LL; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia. pavlikl@mail.ru., Mikheeva IB; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia., Al'-Mugkhrabi YM; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia., Berest VP; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia., Kirova YI; Research Institute of General Pathology and Pathophysiology, Moscow, Russia., Germanova EL; Research Institute of General Pathology and Pathophysiology, Moscow, Russia., Luk'yanova LD; Research Institute of General Pathology and Pathophysiology, Moscow, Russia., Mironova GD; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2018 Jan; Vol. 164 (3), pp. 376-381. Date of Electronic Publication: 2018 Jan 08.
DOI: 10.1007/s10517-018-3993-1
Abstrakt: We performed ultrastructural study of cerebral cortex mitochondria in rats with different tolerance to oxygen deficiency (low resistant and highly resistant specimens). Low resistant rats were characterized by the prevalence of mitochondria with lightened matrix due to the nondense packing of cristae. By contrast, mitochondria of highly resistant animals had the dense packing of cristae. The structure of mitochondria underwent adaptive changes at 14-10% O 2 in the inspired air. Under these conditions, structural characteristics of the cerebral cortex in hypoxia-sensitive rats resembled those in resistant animals. The decrease in O 2 concentration to 8% was accompanied by ultrastructural signs of mitochondrial damage, which correlated with de-energization of the cell and dysfunction of adaptive signaling systems. Ultrastructural features of cerebral cortex mitochondria in animals with low and high tolerance to acute oxygen deficiency confirm the hypothesis that they are associated with two different "functionaland-metabolic portraits".
Databáze: MEDLINE
Externí odkaz: